Division of Pulmonary, Critical Care & Sleep Medicine

Antonino Catanzaro, M.D.

Professor of Medicine

Director, Tuberculosis Control

CLINICAL INTERESTS:

Chronic pulmonary infections, particularly tuberculosis, other mycobacterial infections, coccidioidomycosis, other fungal infections, and community-acquired and nosocomial pneumonias.

INVESTIGATIVE INTERESTS:

Operational research in tuberculosis prevention, diagnosis, treatment, education, and public health and economic issues; basic research on the molecular basis of the interaction between mycobacteria and host cells, particularly mononuclear cells and epithelial cells. Clinical trials for the treatment of tuberculosis, fungal lung disease and pneumonia.

SELECTED PUBLICATIONS:

  1. Rao SP, Ogata K, Catanzaro A. Mycobacterium avium-M. intracellulare binds to the integrin receptor av b3 on human monocytes and monocyte-derived macrophages. Infect Immun 1993;61(2):663-70.
  2. Rao SP, Ogata K, Morris SL, Catanzaro A. Identification of a 68 kD surface antigen of Mycobacterium avium that binds to human macrophages. J Lab Clin Med 1994;123(4):526-35.
  3. Catanzaro A, Galgiani JN, Levine BE, Sharkey-Mathis PK, Fierer J, Stevens DA, Chapman SW, Cloud G, and others in the NIAID Mycoses Study Group. Fluconazole in the treatment of chronic pulmonary and nonmeningeal disseminated coccidioidomycosis. Am J Med 1995;48:249-56.
  4. Bradley SP, Reed SL, Catanzaro A. Clinical efficacy of the amplified Mycobacterium tuberculosis direct test for the diagnosis of pulmonary tuberculosis. Am J Respir Crit Care Med 1996;153:1606-10.
  5. Rao SP, Ratnaker P, Catanzaro A. Macrophage release of tumor necrosis factor - by Mycobacterium avium antigens. FEMS Immunol Med Microbiol 1996;15:27-34.
  6. LoBue PA, Catanzaro A. TB or not TB? Rapid tests for pulmonary tuberculosis. J Respir Dis 1997;18(3):299-308.
  7. Hayashi T, Rao SP, Catanzaro A. Binding of the 68-kilodalton protein of Mycobacterium avium to v 3 on human monocyte-derived macrophages enhances complement receptor type 3 expression. Infect Immun 1997;65(4):1211-6.
  8. American Thoracic Society Workshop Report (Catanzaro A, Chairman). Rapid diagnostic tests for tuberculosis. What is the appropriate use? Am J Respir Crit Care Med 1997;155:1804-14.
  9. Hayashi T, Rao SP, Catanzaro A. Apoptosis of human monocytes and macrophages by Mycobacterium avium sonicate. Infect Immun 1997;65(12):5262-71.
  10. LoBue PA, Catanzaro A. Effectiveness of a nosocomial tuberculosis control program at an urban teaching hospital. Chest 1998;113(5):1184-9.
  11. Villarino ME, Burman W, Wang Y-C, Lundergan L, Catanzaro A, Bock N, Jones C, Nolan C. Comparable specificity of 2 commercial tuberculin reagents in persons at low risk for tuberculous infection. JAMA 1998;281(2):169-71.
  12. Hayashi T, Rao SP, Meylan PR, Kornbluth RS, Catanzaro A. Role of CD40 ligand in Mycobacterium avium infection. Infect Immun 1999:67(7):3558-65.
  13. Mathur ML, LoBue PA, Catanzaro A. Evaluation of serologic test for the diagnosis of tuberculosis. Int J Tuberc Lung Dis 1999;3(8):732-5.
  14. Catanzaro, A, Perry, S, Clarridge, JE, Dunbar, S, Goodnight-White, S, LoBue, PA, Peter, C, Pfyffer, GE, Sierra, MF, Weber, R, Woods, G, Mathews, G, Jonas, V, Smith, K, and Della-Latta, P. The Role of Clinical Suspicion in Evaluating a New Diagnostic Test for Active Tuberculosis. JAMA, 283(5):639-645, 2000.
  15. Stevens, DA, Schwartz, HJ, Lee, JY, Moskovitz, BL, Jerome, DC, Catanzaro, A, Bamberger, DM, Weinmann, AJ, Tuazon, CU, Judson, MA, Platts-Mills, TAE, DeGraff, AC, Jr., Grossman, J, Slavin, RG and Reuman, P. A Randomized Trial of Itraconazole in Allergic Bronchopulmonary Aspergillosis. New Engl J Med, 342(11):756-762, 2000.
  16. Villarino, ME, Brennan, MJ, Nolan, CM, Catanzaro, A, Lundergan, LL, Bock, NN, Jones, CL, Wang, Y-C and Burman, W.J. Comparison Testing of Current (PPD-S1) and Proposed (PPD-S2) Reference Tuberculin Standards. Am J. Respir Crit Care Med, 161:1167-1171, 2000.
  17. Galgiani, JN, Ampel, NM, Catanzaro, A, Johnson, RH, Stevens, DA and Williams, PL. Practice Guidelines for the Treatment of Coccidioidomycosis. Clin Infect Dis, 30:658-661, 2000.
  18. LoBue, P and Catanzaro, A. Diagnosing tuberculosis: Facts and fallacies. J Respir Dis, 21(6):377-388, 2000.
  19. Galgiani, J.N., Catanzaro, A., Cloud, G.A., Johnson, R.H., Williams, P.L., Mirels, L.F., Nassar, F., Lutz, J.E. Stevens, D.A., Sharkey, P.K., Singh, V.R., Larsen, R.A, Delgado, K.L., Flanigan, C., Rinaldi, M.G. and the NIAID Mycoses Study Group: Comparison of Oral Fluconazole and Itraconazole for Progressive, Nonmeningeal Coccidioidomycosis. Ann Intern Med, 133:676-686, 2000.
  20. Hayashi, T., Rao, S.P., Takabayashi, K., Van Uden, J.H., Kornbluth, R.S., Baird, S.M., Taylor, M.W., Carson, D.A., Catanzaro, A. and Raz, E.: Enhancement of Innate Immunity against Mycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase. Infect Immun 69(10): 6156-6164, 2001.
  21. The Tuberculosis Trials Consortium*: Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet, 360:528-34, 2002. *A. Catanzaro, UCSD site Principal Investigator of the Tuberculosis Trials Consortium.

PubMed

Board Certification:

  • Internal Medicine
  • Pulmonary Disease

To schedule an appointment with Dr. Catanzaro, contact Deborah Gaddy at (858) 657-8440. To reach his administrative assistant, contact Vickie Saddler at (858) 534-9139.

To contact Dr. Catanzaro: acatanzaro@ucsd.edu