Division of Pulmonary, Critical Care & Sleep Medicine

Jose Loredo, M.D., M.S., M.P.H.

Professor of Clinical Medicine

Chief, Sleep Medicine Section, VAMC

 

CLINICAL AND INVESTIGATIVE INTERESTS:

Treatment and investigation of patients with sleep disorders: I am currently conducting a large epidemiological NIH sponsored study to evaluate the ethnic differences in sleep-health and sleep-health knowledge between Hispanics of Mexican descent and Caucasians in San Diego County.  I am also interested in the association of snoring-sleep apnea and nocturnal asthma exacerbation. I continue to investigate the role of chemoreceptors in hypertension and obstructive sleep apnea, and the role of micro-arousals from sleep in the activation of the sympathetic nervous system and daytime functioning. We also have NIH sponsored studies looking at the effects of treatment of sleep apnea in Parkinson’s disease and patients with a recent stroke, the effect of CPAP on inflammation in sleep apnea patients, the prevalence of sleep disordered breathing in patients with CHF, and enhancing compliance with CPAP therapy. Other current research projects include the role of sleep duration in the health of U.S. Latinos; Effects of inhaled corticosteroids in the collapsibility of the upper airway and obstructive sleep apnea in asthmatics; Effectiveness of the diagnosis and treatment of sleep apnea using only unattended home sleep studies.

SELECTED PUBLICATIONS:

  1. Loredo JS, Clausen JL, Ancoli-Israel S, Dimsdale JE. Night-to-night arousal variability and interscorer reliability of arousal measurements. Sleep 1999;22(7):916-20.

  2. Loredo JS, Ziegler MG, Ancoli-Israel S, Clausen JL, Dimsdale JE. Relationship of arousals from sleep to sympathetic nervous system activity and blood pressure in obstructive sleep apnea. Chest 1999;116(3):655-9.

  3. Loredo JS, Clausen JL, Nelesen RA, Ancoli-Israel S, Ziegler MG, Dimsdale JE. Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved? Med Hypotheses 2001 Jan;56(1):17-19.

  4. Ziegler MG, Mills PJ, Loredo JS, Ancoli-Israel S, Dimsdale JE. Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea. Chest. 2001 Sep;120(3):887-93.

  5. Loredo JS, Ancoli-Israel S, Dimsdale JE. Sleep quality and blood pressure dipping in obstructive sleep apnea. Am J Hypertens. 2001 Sep;14(9 Pt 1):887-92.

  6. Loredo JS, Nelesen R, Ancoli-Israel S, Dimsdale JE. Sleep quality and blood pressure dipping in normal adults. SLEEP 27(6):1097-1103, 2004 Sep

  7. von Känel R, Loredo JS, Powell FL, Adler KA, Dimsdale JE Short-term isocapnic hypoxia and coagulation activation in patients with sleep apnea. Clin Hemorheol Microcirc 33(4): 369-377, 2005

  8. Mills PJ, Kennedy BP, Loredo JS, Dimsdale JE, Ziegler MG. Effects of Nasal Continuous Positive Airway Pressure and Oxygen Supplementation on Norepinephrine Kinetics and Cardiovascular Responses in Obstructive Sleep Apnea. J Appl Physiol 100(1): 343-348, 2006 Jan

  9. von Känel R, Loredo JS, Ancoli-Israel S, Dimsdale JE. Association between sleep apnea severity and blood coagulability: Treatemtn effects of nasal continuous positive airway pressure. Sleep Breath 10(3):139-46, 2006 Sep

  10. Norman D, Loredo JS, Nelesen RA, Ancoli-Israel S, Mills PJ, Ziegler MG, Dimsdale JE. Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure. Hypertension 47:1-6, 2006 Apr

  11. Loredo JS, Ancoli-Israel S, Kim EJ, Lim WJ, Dimsdale JE. Effect of continuous positive airway pressure versus supplemental oxygen on sleep quality in obstructive sleep apnea: a placebo-CPAP-controlled study. SLEEP 29(4):564-71, 2006 Apr

  12. Cooke J, Loredo JS, Liu L, Marler M, Corey-Bloom J, Fiorentino L, Harrison T, Ancoli-Israel S. Acetylcholinesterase Inhibitors and Sleep Architecture in Patients with Alzheimer's Disease. Drugs Aging 23(6):503-11, 2006

  13. Choi JB, Loredo JS, Norman D, Mills PJ, Ancoli-Israel S, Ziegler MG, Dimsdale JE. Does obstructive sleep apnea increase hematocrit? Sleep Breath 10(3):155-60, 2006 Sep

  14. Loredo JS, Berry C, Nelesen RA, Dimsdale JE. Prediction of Continuous Positive Airway Pressure in Obstructive Sleep Apnea. Sleep Breath 11(1):45-51, 2007 Mar

  15. Norman D, Bardwell WA, Loredo JS, Ancoli-Israel S, Heaton RK, Dimsdale JE. Caffeine Intake is Independently Associated with Neuropsychological Performance in Patients with Obstructive Sleep Apnea. Sleep Breath. 2008 Aug;12(3):199-205

  16. Nelson JA, Loredo JS, Acosta JA. The Obesity-Hypoventilation Syndrome and Respiratory Failure in the Acute Trauma Patient. J Emerg Med 2008 Aug 30. [Epub ahead of print]

  17. Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Liu L, Ayalon L, He F, Loredo JS. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc. 2008 Nov;56(11):2076-81

PubMed:

Board Certified:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine
  • Sleep Medicine
    • American Board of Sleep Medicine
    • ABIM Sleep Medicine

UCSD Sleep Medicine Center

To schedule an appointment with Dr. Loredo, contact 619-543-5713

To contact Dr. Loredo: jloredo@ucsd.edu