Division of Pulmonary, Critical Care & Sleep Medicine

Timothy Morris, M.D.

Professor of Clinical Medicine

Clinical Service Chief - UCSD Medical Center (Hillcrest)

Director, Clinical Pulmonary Services, UCSD Hillcrest

Medical Director, Respiratory Care

Medical Director, Pulmonary Function Laboratory

 

SPECIAL CLINICAL INTERESTS:

  1. General pulmonary medicine
  2. Acute pulmonary thromboembolic disease
  3. Critical Care

 

INVESTIGATIVE INTEREST:

  1. Acute pulmonary thromboembolic disease

 

SELECTED PUBLICATIONS:

  1. Yi ES, Auger WR, Friedman PJ, Morris TA, Shin SS. Intravascular Bronchioloalveolar Tumor of the Lung Presenting as Pulmonary Thromboembolic Disease and Pulmonary Hypertension. Archives of Pathology and Laboratory Medicine 119:255-260.1995 (Original Research Article)
  2. Morris TA, Auger WR, Ysrael MZ, Olson LK, Channick RN, Fedullo PF, Moser KM. Parenchymal Scarring Is Associated With Restrictive Spirometric Defects in Patients With Chronic Thromboembolic Pulmonary Hypertension.  Chest 110:399-403.1996 (Original Research Article)
  3. Morris TA, Marsh JJ, Fagnani R, Hagan M,  Moser KM.  Degree of Polymer Organization Decreases the Binding of a Monoclonal Antibody Raised Against the -Chain Amino Terminus of  Fibrin.  Thrombosis and Haemostasis 77:704-709. 1997 (Original Research Article)
  4. Morris T.A., Marsh J.J., Konopka R., Pedersen C.A., Chiles P.G., Fagnani R., Hagan M., Moser K.M.. Antibodies Against the Fibrin $-Chain Amino Terminus Detect Active Canine Venous Thrombi Circulation 96(9):3173-3179. 1997 (Original Research Article)
  5. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Endothelin mediates pulmonary vascular remodeling in a canine model of chronic embolic pulmonary hypertension.  European Respiratory Journal 15:640-648. 2000 (Original Research Article)
  6. Kim H, Yung GL, Morris T.A., Marsh JJ, Chiles PG, Pedersen C, et al. Endothelin Antagonism Inhibits Pulmonary Vascular Remodeling In Canine Chronic Pulmonary Embolism. American Journal of Respiratory and Critical Care Medicine 1999;159(3):566.
  7. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase.  Experimental Lung Research 26:287-301. 2000 (Original Research Article)
  8. Yi ES, Kim H, Ahn H, Strother J, Morris T, Masliah E, Hansen LA, Park K, Friedman PJ: Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study. American Journal of Respiratory and Critical Care Medicine 162:1577-1586. 2000 (Original Research Article)
  9. Morris TA, Marsh JJ, Konopka R, Pedersen CA, Chiles PG. Anti-thrombotic efficacies of enoxaparin, dalteparin, and unfractionated heparin in venous thrombo-embolism. Thrombosis Research. 100:185-94.  2000 (Original Research Article)
  10. Morris TA, Marsh JJ, Burrows CM, Chiles PG, Konopka R, Pedersen CA.  Urine and Plasma Levels of Fibrinopeptide B in Patients with Deep Vein Thrombosis and Pulmonary Embolism. Thrombosis Research; 110(2-3):159-65. 2003 (Original Research Article)
  11. Morris TA, Marsh JJ, Chiles PG, Konopka RG, Pedersen CA, Schmidt PF, Gerometta M. Single Photon Emission Computed Tomography of Pulmonary Emboli and Venous Thrombi Using Anti-D-dimer. American Journal of Respiratory and Critical Care Medicine. 169(9);987-93. 2004 (Original Research Article)
  12. Morris TA, Marsh JJ, Chiles PG, Pedersen CA, Konopka RG, Gamst AC, Loza O. Embolization Itself Stimulates Thrombus Propagation in Pulmonary Embolism. American Journal of Physiology - Heart and Circulatory Physiology. 287(2):H818-22. 2004 (Original Research Article)
  13. Morris TA, Marsh JJ, Konopka R, Pedersen CA, Chiles PG. Improved imaging of deep venous thrombi during anticoagulation using radiolabelled anti-D-dimer antibodies. Nuclear Medicine Communications. 25(9):917-922. 2004 (Original Research Article)
  14. Morris TA, Jacobson A, Marsh JJ, Lane JR. Pharmacokinetics of UH and LMWH are similar with respect to antithrombin activity. Thrombosis Research 115(1-2):45-51. 2005 (Original Research Article)
  15. Stone SE, Morris TA. Pulmonary embolism during and after pregnancy. Critical Care Medicine.  33(10 Suppl):S294-300. 2005 (Review Article)
  16. Morris TA, Marsh JJ, Chiles PG, Auger WR, Fedullo PF, Woods VL Jr. Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. Am J Respir Crit Care Med 173:1270-1275. 2006 (Original Research Article)
  17. Morris TA, Marsh JJ, Chiles PG, Kim NH, Noskovack KJ, Magana MM, Gruppo RA, Woods VL Jr. Abnormally sialylated fibrinogen gamma-chains in a patient with chronic thromboembolic pulmonary hypertension. Thromb Res 119:257-259. 2007 (Original Research Article)
  18. Morris TA, Castrejon S, Devendra G, Gamst AC 2007. No Difference In Risk For Thrombocytopenia During Treatment Of Pulmonary Embolism & Deep Venous Thrombosis With Either Low Molecular Weight Heparin Or Unfractionated Heparin: a meta-analysis. Chest. 132(4):1131-1139. 2007 (Meta-analysis/Structured Evidence Review)
  19. Anderson DR, Kahn SR, Rodger MA, Kovacs MJ, Morris T, Hirsch A, Lang E, Stiell I, Kovacs G, Dreyer J, Dennie C, Cartier Y, Barnes D, Burton E, Pleasance S, Skedgel C, O'Rouke K, Wells PS. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA 298(23):2743-2753. 2007 (Original Research Article)
  20. Firth A.L., Yau J., White A., Chiles P.G., Marsh J.J., Morris T.A., Yuan J.X.. Chronic exposure to fibrin and fibrinogen differentially regulates intracellular ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 296(6):L979-986. 2009 (Original Research Article)
  21. Morris T.A., Marsh JJ, Chiles PG, Magana MM, Liang NC, Soler X, Desantis DJ, Ngo D, Woods VL, Jr. High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood.114(9):1929-1936. 2009 (Original Research Article)
  22. Maynard GA, Morris TA, Jenkins IH, Stone S, Lee J, Renvall M, Fink E, Schoenhaus R. Optimizing prevention of hospital-acquired venous thromboembolism (VTE): prospective validation of a VTE risk assessment model. J Hosp Med. 5(1):10-18. 2010 (Original Research Article)
  23. Matchar DB, Jacobson A, Dolor R, Edson R, Uyeda L, Phibbs CS, Vertrees JE, Shih MC, Holodniy M, Lavori P. Effect of home testing of international normalized ratio on clinical events. N Engl J Med.363(17):1608-1620. (Morris T.A.: Data Safety and Management Board) 2010 (Original Research Article)
  24. Soler X., Hoh C.K., Test V.J., Kerr K.M., Marsh J.J., Morris T.A.. Single Photon Emission Computed Tomography in Chronic Thromboembolic Pulmonary Hypertension. Respirology. 16(1):131-137. 2011 (Original Research Article)
  25. Morris T.A., Gerometta M., Smart R.C., Eisenberg P., Roach P.J., Tsui W.W., Better N., Taubman K.L., Unger S.A., Macfarlane D. Pulmonary Emboli Imaging with 99mTc-labeled Anti-D-dimer (DI-80B3) Fab' Followed by SPECT.  Heart, Lung and Circulation. 20(8):503-11. 2011(Original Research Article)
  26. Morris T.A., Gerometta M., Yusen R.D., White R.H., Douketis J.D., Kaatz S.S., Smart R.C., Macfarlane D., Ginsberg J.S.. Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab’ Fragments (ThromboView).  American Journal of Respiratory and Critical Care Medicine. 184:708-14. 2011 (Original Research Article)
  27. Cummins S, Zhu SH, Gamst A, Kirby C, Brandstein K, Klonoff-Cohen H, Chaplin E, Morris T, Seymann G, Lee J. Nicotine patches and quitline counseling to help hospitalized smokers stay quit: study protocol for a randomized controlled trial. Trials.;13:128. 2012 Role: assisted with trial planning and study procedures. (Original Research Article)
  28. Soler X, Kerr KM, Marsh JJ, Renner JW, Hoh CK, Test VJ, Morris TA. Pilot study comparing SPECT perfusion scintigraphy with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension. Respirology. 17(1):180-4. 2012 Role: principal investigator (Original Research Article)
  29. Douketis JD, Ginsberg JS, Haley S, Julian J, Dwyer M, Levine M, Eisenberg PR, Smart R, Tsui W, White RH, Morris TA, Kaatz S, Comp PC, Crowther MA, Kearon C, Kassis, J, Bates S, Schulman S, Desjardins L, Taillefer R, Begelman SM, Gerometta M.  Accuracy and safety of (99m)Tc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView(R)) in the diagnosis of deep vein thrombosis: a phase II study. Thrombosis Research. 130(3):381-9. 2012 Role: assisted in design of imaging agent, steering section for trial, analyzed results and helped write manuscript. (Original Research Article)
  30. Marsh JJ, Guan HS, Li S, Chiles PG, Tran D, Morris TA. Structural insights into fibrinogen dynamics using amide hydrogen/deuterium exchange mass spectrometry. Biochemistry. 52(32):5491-502. 2013 Role: principal investigator (Original Research Article)
  31. Marsh JJ, Chiles PG, Liang NC, Morris TA. Chronic thromboembolic pulmonary hypertension-associated dysfibrinogenemias exhibit disorganized fibrin structure. Thrombosis Research.132(6):729-34. 2013 Role: principal investigator (Original Research Article)
  32. Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA and Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PloS one. 9:e99847. 2014 Role: assisted with planning of deuterium exchange mass spectrometry (Original Research Article)
  33. Kearon C, Akl EA, Ornelas J, Blaivas A, Jimenez D, Bounameaux H, Huisman M, King CS, Morris TA, Sood N, Stevens SM, Vintch JR, Wells P, Woller SC and Moores L. Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report. Chest.149:315-52. 2016 Role: primary data synthesis for catheter-assisted therapy for pulmonary embolism and for extended treatment of venous thromboembolism; analyzed data for all other therapeutic modalities, manuscript preparation (Meta-analysis/Structured Evidence Review)
  34. Morris TA, Gay PC, MacIntyre NR, Hess DR, Hanneman SK, Lamberti JP, Doherty DE, Chang L and Seckel MA. Respiratory Compromise as a New Paradigm for the Care of Vulnerable Hospitalized Patients. Respiratory Care.62:497-512. 2017 (Meta-analysis/Structured Evidence Review) PMID: 28559470
  35. Oh A, Morris TA, Yoshii IT, Morris TA. Flow Decay: a Novel Spirometric Index to Quantify Dynamic Airway Resistance. Respiratory Care 2017 Jul;62(7):928-935. doi: 10.4187/respcare.04850. Epub 2017 May 30, 2017.  PMID: 28559470  Role: principal investigator (Original Research Article)

    AWARDS AND HONORS:
  • President, National Association for Medical Direction of Respiratory Care 2015 -2017
  • Best Doctors in America. 2015-16
  • American Lung Association in California: San Diego Healthcare Provider of the Year 2013
  • Housestaff Teaching Awards 2012, 2013, 2015
  • Distinguished Scholar in Thrombosis, American College of Chest Physicians 2003-2006 (inaugural awardee)
  • President, California Thoracic Society 2003-2004

BOARD CERTIFICATIONS:
             Critical Care Medicine
                 Pulmonary Disease

PubMed:

UCSD Pulmonary Function and Exercise Lab

For a Pulmonary consultation, please call our toll-free line: 855-355-5867 (LUNG).