Division of Pulmonary, Critical Care & Sleep Medicine

Praveen Akuthota, MD

Associate Clinical Professor

Associate Program Director, PCCM Fellowship

CLINICAL INTERESTS:

  • Asthma
  • Eosinophilic Pulmonary Disease - including EGPA (Churg-Strauss syndrome), eosinophilic pneumonias, allergic bronchopulmonary aspergillosis, and hypereosinophilic syndromes
  • Critical Care Medicine

Dr. Akuthota maintains an active clinical practice with a focus on asthma and eosinophilic pulmonary disease, with expertise in biologic therapies. His practice is located at the UC San Diego Health Executive Drive location (for information see: health.ucsd.edu/specialties/pulmonary/Pages/default.aspx ). He is also an attending physician in the medical ICU at the UC San Diego Hillcrest Medical Center.

INVESTIGATIVE INTERESTS:

Dr. Akuthota’s research efforts range from basic scientific investigations of human eosinophil biology and eosinophilic inflammation to clinical and translational efforts in asthma and eosinophilic pulmonary disease. He is the corresponding Principal Investigator for the UCSD Clinical Center in the National Heart, Lung, and Blood Institute’s PrecISE Network that will be studying precision interventions in severe asthma. He is a co-investigator on a study published in the New England Journal of Medicine showing the efficacy of anti-IL-5 therapy in the treatment of the eosinophilic disease EGPA (Churg Strauss syndrome). His research group is involved in other multicenter studies in eosinophilic disease and asthma. He is a Clinical Affiliate at the La Jolla Institute for Allergy and Immunology, working with them in developing joint efforts in asthma research (www.togetherforasthma.org). Basic science investigations from Dr. Akuthota focus on ex vivo studies of human eosinophils and include published work studying eosinophil trafficking and work studying microparticle release by eosinophils. He has written several reviews and chapters discussing eosinophil immunobiology and clinical considerations in eosinophilic diseases. Dr. Akuthota is an At-Large Member of the Board of Directors of the International Eosinophil Society (http://www.eosinophil-society.org/).

SELECTED PUBLICATIONS

Original Peer-Reviewed Work
  1. Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini A, Buettner C, Akuthota P. Coenzyme Q10 Levels are Low and Are Associated with the Inflammatory Cascade in Septic Shock. Crit Care. 2011; 15(4):R189.
  2. Akuthota P, Spencer LA, Melo RC, Weller PF. MHC Class II and CD9 in Human Eosinophils Localize to Detergent-Resistant Membrane Microdomains. Am J Respir Cell Mol Biol. 2012; 46(2):188-195.
  3. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation. 2012; 83(8):991-995.
  4. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, DeCamp MM, Berger RL. An Evidence-Based Estimate on the Size of the Potential Patient Pool for Lung Volume Reduction Surgery. Ann Thorac Surg. 2012; 94(1):205-211.
  5. Akuthota P, Ueki S, Estanislau J, Weller PF. Human Eosinophils Express Functional CCR7. Am J Respir Cell Mol Biol. 2013; 48(6):758-764.
  6. Estanislau J, Danielson K, Tigges J, Toxavidis V, Camacho V, Kreimer S, Ivanov AR, Mantel P, Akuthota P, Das S, Ghiran I. Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry. PLoS One. 2016; 2016 Jan 8; 11(1):e0144678.
  7. Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC. Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli. Front Cell Dev Biol. 2016; Oct 27;4: Article117.
  8. Wang H (co-first author), Akuthota P (co-first author), Kanaoka Y, Weller PF. Airway Eosinophil Migration into Lymph Nodes in Mice Depends on Leukotriene C4. Allergy. 2016; Nov 22 [Epub ahead of print]
  9. Dewitz C, McEachern E, Shin S, Akong K, Nagle DG, Broide DH, Akuthota P, Crotty Alexander LE. Hypoxia Inducible Factor-1α Inhibition Modulates Airway Hyperresponsiveness and Nitric Oxide Levels in a BALB/c Mouse Model of Asthma. Clin Immunol. 2017; 176: 94-99.
  10. Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA, Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ, EGPA Mepolizumab Study Team. Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. N Engl J Med. 2017; 376(20):1921-1932.
  11. Marshall DC, Salciccioli JD, Shea BS, Akuthota P. Trends in Mortality from Idiopathic Pulmonary Fibrosis in the European Union: An Observational Study of the WHO mortality database from 2001– 2013. Eur Respir J. 2018, 519(1): pii: 1701603.
 
Methods
  1. Akuthota P, Shamri R, Weller PF. Isolation of Human Eosinophils. Current Protocols in Immunology. 2012; 98:7.31.1-7.31.8.
  2. Akuthota P. Eosinophil Interactions: Antigen Presentation. Methods Mol Biol. 2014; 1178: 251-255.
  3. Akuthota P, Capron K, Weller PF. Eosinophil Purification from Peripheral Blood. Methods Mol Biol. 2014; 1178: 13-20.
 
Review and Invited Articles
  1. Akuthota P, Wang H, Spencer LA, Weller PF. Immunoregulatory Roles of Eosinophils: A New Look at a Familiar Cell. Clin and Exp Allergy. 2008; 38(8):1254-1263.
  2. Akuthota P, Wang H, Weller PF. Eosinophils as Antigen-Presenting Cells in Allergic Upper Airway Disease. Curr Opin Allergy Clin Immunol. 2010; 10(1):14-19.
  3. Akuthota P, Xenakis JJ, Weller PF.  Eosinophils: Offenders or General Bystanders in Allergic Airway Disease and Pulmonary Immunity?  J Innate Immun. 2011; 3(2):113-119. 
  4. Akuthota P, Weller PF. Eosinophils and Disease Pathogenesis. Semin Hematol. 2012; 49(2):113-119.
  5. Akuthota P, Weller PF. Eosinophilic Pneumonias. Clin Microbiol Rev. 2012; 25(4):649-660.
  6. Akuthota P, Weller PF. Spectrum of Eosinophilic End-Organ Manifestations. Immunol Allergy Clin North Am. 2015, 35(3):403-411.
  7. Akuthota P, Fischer A, Wechsler M. Eosinophilia: A Practical Guide for the Rheumatologist. The Rheumatologist. June 15, 2015.
  8. Crouch DR, Akuthota P. Asthma at the 2016 American Thoracic Society International Conference. J Thorac Dis. 2016; 8(Suppl 7):S556-8.
  9. Michaud GC, Channick CL, Law AC, McCannon JB, Antkowiak M, Garrison G, Sayah D, Huynh RH, Brady AK, Adamson R, DuBrock H, Akuthota P, Marion C, Dela Cruz C, Town JA, Çoruh B, Thomson CC. ATS Core Curriculum 2016. Part IV. Adult Pulmonary Medicine Core Curriculum. Ann Am Thorac Soc. 2016; 13:1160-1169.
Books and Book Chapters
  1. Akuthota P, Xenakis J, Wang H, Weller PF. Eosinophil-Mediated Antigen Presentation. In: Eosinophils in Health and Disease. Academic Press (Elsevier); 2013. p. 346-350. (Lee JJ and Rosenberg HF, editors.)
  2. Akuthota P, Wechsler ME. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia. In: Harrison’s Principles of Internal Medicine, 19th edition. McGraw-Hill Professional; 2015. p. 1681-1687. (Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors.)
  3. Akuthota P, Weller PF. Clinical Manifestations and Diagnosis of Allergic Bronchopulmonary Aspergillosis. In: UpToDate. UpToDate, Waltham, MA; 2016. (Post TW, editor.)
  4. Akuthota P, Weller PF. Treatment of Allergic Bronchopulmonary Aspergillosis. In: UpToDate. UpToDate, Waltham, MA; 2016. (Post TW, editor.)


HONORS and AWARDS

  • Outstanding Resident Teacher Award, Beth Israel Deaconess Med Center (2006)
  • AII Travel Award, American Thoracic Society (2008)
  • Invited Participant, Respiratory Diseases Young Investigators’ Forum (2008)
  • Invited Participant, Clinical Immunology Society Hypersensitivity School (2008)
  • Travel Award, Clinical Immunology Society Advanced Course (2009)
  • NIH Individual National Research Service Award (F32) (2009)
  • American Partnership for Eosinophilic Disorders, HOPE Pilot Award (2013)
  • NIH/NHLBI K08 Career Development Award (2014)

BOARD CERTIFICATIONS

Pulmonary Disease
Critical Care Medicine
Internal Medicine