Division of Pulmonary, Critical Care & Sleep Medicine

Praveen Akuthota, MD

Associate Clinical Professor

CLINICAL INTERESTS:

  • Eosinophilic Pulmonary Disease - including EGPA (Churg-Strauss syndrome), eosinophilic pneumonias, allergic bronchopulmonary aspergillosis, and hypereosinophilic syndromes
  • Asthma
  • Critical Care Medicine

INVESTIGATIVE INTERESTS:

Dr. Akuthota’s research efforts center around basic scientific investigations of human eosinophil biology, in particular as applicable to allergic pulmonary inflammation. Recent published work demonstrates that human eosinophils express functional CCR7, a key chemokine receptor involved in leukocyte trafficking. Other areas of interest include exosome and microvesicle release by eosinophils. Dr. Akuthota has been active as a co-investigator in a multi-center study of the efficacy of anti-IL-5 monoclonal antibody in the treatment of Churg-Straus syndrome (EGPA), a systemic eosinophilic disorder. He has written several reviews and chapters discussing clinical and translational considerations in eosinophilic diseases.

SELECTED PUBLICATIONS

Original Peer-Reviewed Work
  1. Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini A, Buettner C, Akuthota P. Coenzyme Q10 Levels are Low and Are Associated with the Inflammatory Cascade in Septic Shock. Crit Care. 2011; 15(4):R189.
  2. Akuthota P, Spencer LA, Melo RC, Weller PF. MHC Class II and CD9 in Human Eosinophils Localize to Detergent-Resistant Membrane Microdomains. Am J Respir Cell Mol Biol. 2012; 46(2):188-195.
  3. Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation. 2012; 83(8):991-995.
  4. Akuthota P, Litmanovich D, Zutler M, Boiselle PM, Bankier AA, Roberts DH, Celli BR, DeCamp MM, Berger RL. An Evidence-Based Estimate on the Size of the Potential Patient Pool for Lung Volume Reduction Surgery. Ann Thorac Surg. 2012; 94(1):205-211.
  5. Akuthota P, Ueki S, Estanislau J, Weller PF. Human Eosinophils Express Functional CCR7. Am J Respir Cell Mol Biol. 2013; 48(6):758-764.
  6. Estanislau J, Danielson K, Tigges J, Toxavidis V, Camacho V, Kreimer S, Ivanov AR, Mantel P, Akuthota P, Das S, Ghiran I. Diurnal variations of circulating extracellular vesicles measured by nano flow cytometry. PLoS One. 2016; 2016 Jan 8; 11(1):e0144678.
  7. Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC. Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli. Front Cell Dev Biol. 2016; Oct 27;4: Article117.
  8. Wang H (co-first author), Akuthota P (co-first author), Kanaoka Y, Weller PF. Airway Eosinophil Migration into Lymph Nodes in Mice Depends on Leukotriene C4. Allergy. 2016; Nov 22 [Epub ahead of print]
 
Methods
  1. Akuthota P, Shamri R, Weller PF. Isolation of Human Eosinophils. Current Protocols in Immunology. 2012; 98:7.31.1-7.31.8.
  2. Akuthota P. Eosinophil Interactions: Antigen Presentation. Methods Mol Biol. 2014; 1178: 251-255.
  3. Akuthota P, Capron K, Weller PF. Eosinophil Purification from Peripheral Blood. Methods Mol Biol. 2014; 1178: 13-20.
 
Review and Invited Articles
  1. Akuthota P, Wang H, Spencer LA, Weller PF. Immunoregulatory Roles of Eosinophils: A New Look at a Familiar Cell. Clin and Exp Allergy. 2008; 38(8):1254-1263.
  2. Akuthota P, Wang H, Weller PF. Eosinophils as Antigen-Presenting Cells in Allergic Upper Airway Disease. Curr Opin Allergy Clin Immunol. 2010; 10(1):14-19.
  3. Akuthota P, Xenakis JJ, Weller PF.  Eosinophils: Offenders or General Bystanders in Allergic Airway Disease and Pulmonary Immunity?  J Innate Immun. 2011; 3(2):113-119. 
  4. Akuthota P, Weller PF. Eosinophils and Disease Pathogenesis. Semin Hematol. 2012; 49(2):113-119.
  5. Akuthota P, Weller PF. Eosinophilic Pneumonias. Clin Microbiol Rev. 2012; 25(4):649-660.
  6. Akuthota P, Weller PF. Spectrum of Eosinophilic End-Organ Manifestations. Immunol Allergy Clin North Am. 2015, 35(3):403-411.
  7. Akuthota P, Fischer A, Wechsler M. Eosinophilia: A Practical Guide for the Rheumatologist. The Rheumatologist. June 15, 2015.
  8. Crouch DR, Akuthota P. Asthma at the 2016 American Thoracic Society International Conference. J Thorac Dis. 2016; 8(Suppl 7):S556-8.
  9. Michaud GC, Channick CL, Law AC, McCannon JB, Antkowiak M, Garrison G, Sayah D, Huynh RH, Brady AK, Adamson R, DuBrock H, Akuthota P, Marion C, Dela Cruz C, Town JA, Çoruh B, Thomson CC. ATS Core Curriculum 2016. Part IV. Adult Pulmonary Medicine Core Curriculum. Ann Am Thorac Soc. 2016; 13:1160-1169.

Books and Book Chapters
  1. Akuthota P, Xenakis J, Wang H, Weller PF. Eosinophil-Mediated Antigen Presentation. In: Eosinophils in Health and Disease. Academic Press (Elsevier); 2013. p. 346-350. (Lee JJ and Rosenberg HF, editors.)
  2. Akuthota P, Wechsler ME. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia. In: Harrison’s Principles of Internal Medicine, 19th edition. McGraw-Hill Professional; 2015. p. 1681-1687. (Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors.)
  3. Akuthota P, Weller PF. Clinical Manifestations and Diagnosis of Allergic Bronchopulmonary Aspergillosis. In: UpToDate. UpToDate, Waltham, MA; 2016. (Post TW, editor.)
  4. Akuthota P, Weller PF. Treatment of Allergic Bronchopulmonary Aspergillosis. In: UpToDate. UpToDate, Waltham, MA; 2016. (Post TW, editor.)


HONORS and AWARDS

  • Outstanding Resident Teacher Award, Beth Israel Deaconess Med Center (2006)
  • AII Travel Award, American Thoracic Society (2008)
  • Invited Participant, Respiratory Diseases Young Investigators’ Forum (2008)
  • Invited Participant, Clinical Immunology Society Hypersensitivity School (2008)
  • Travel Award, Clinical Immunology Society Advanced Course (2009)
  • NIH Individual National Research Service Award (F32) (2009)
  • American Partnership for Eosinophilic Disorders, HOPE Pilot Award (2013)
  • NIH/NHLBI K08 Career Development Award (2014)

BOARD CERTIFICATIONS

Pulmonary Disease
Critical Care Medicine
Internal Medicine