Division of Pulmonary & Critical Care Medicine

Laura E. Crotty Alexander, M.D.

Assistant Clinical Professor of Medicine, UCSD

Staff Physician, VA San Diego Healthcare System

 

 

CLINICAL INTERESTS:

  1. Critical Care Medicine
  2. Asthma
  3. Chronic Inflammatory Lung Disease

 

INVESTIGATIVE INTERESTS:

  1. Asthma
  2. Microbial pathogenesis in the lung
  3. Innate immunity in the lung
  4. Hypoxia inducible factor
  5. Extracellular traps

 

SELECTED PUBLICATIONS:

  1. Vega VL, Charles W, Crotty Alexander LE. Rescuing of deficient killing and phagocytic activities of macrophages dervied from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. Cell Stress Chaperones. 2011 May 29.
  2. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander LE, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial phenol soluble modulins cooperate with host antimicrobial peptides to kill Group A Streptococcus. PLoS ONE. 5(1):e8557, 2010 Jan 5.
  3. Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SHM, Gallo RL, von Köckritz-Blickwede M, Nizet V. M1T1 Group A Streptococcal Pili Promote Epithelial Colonization but Diminish Systemic Virulence Through Neutrophil Extracellular Entrapment. Journal of Molecular Medicine. 2009 Dec 4.
  4. Laugel B, Boulter JM, Lissin N, Vuidepot A, Li Y, Gostrick E, Crotty LE, Douek DC, Hemelaar J, Price DA, Jakobsen BK, Sewell AK. Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry. 280(3):1882-92, 2005 Jan 21.
  5. Crotty LE. Sampson JH. Archer GE, and Bigner DD. Models for CNS malignancies. Pgs 1123-1138. In: Alison MR, ed.  The Cancer Handbook. London: Nature Publishing Group, 2004.
  6. Crotty LE,* Heimberger AB,* Archer GE, Hess KR, Wikstrand CJ, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clinical Cancer Research. 9(11):4247-54, 2003 Sep 15.
  7. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 101(7):2711-20, 2003 Apr 1.
  8. Wikstrand CJ, Cole VR, Crotty LE, Sampson JH, Bigner DD. Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. Cancer Immunology & Immunotherapy. 50(12):639-52, 2002 Feb.
  9. Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 50(1):158-64; discussion 164-6, 2002 Jan.
  10. Crotty LE,* Sampson JH,* Lee S, Archer GE, Ashley DM, Wikstrand CJ, Hale LP, Small C, Dranoff G, Friedman AH, Friedman HS, Bigner DD. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proceedings of the National Academy of Sciences of the United States of America. 97(13):7503-8, 2000 Jun 20.
  11. Heimberger AB, Crotty LE, Archer GE, McLendon RE, Friedman A, Dranoff G, Bigner DD, Sampson JH. Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. Journal of Neuroimmunology. 103(1):16-25, 2000 Feb 1.

*co-first authors

ABSTRACTS (RECENT):

  1. L. E. Crotty Alexander, K. Akong, and V. Nizet. The role of hypoxia inducible factor-alpha subunits in allergic inflammatory airways disease. American Thoracic Society, May 2011 (poster discussion).
  2. L. E. Crotty Alexander, V. Vega and V. Nizet. Changes in bactericidal capacity of macrophages in response to fever. American Thoracic Society, May 2009 (poster).
  3. L. E. Crotty Alexander and V. Nizet. Group A Streptococcal pilus protein spy0128 stimulates host inflammatory responses, leading to decreased virulence in pneumonia and necrotizing fasciitis. American Thoracic Society, May 2009 (poster).

 

HONORS AND AWARDS

  1. 2006 Internal Medicine Residency Humanities Award, Massachusetts General Hospital
  2. 2008 Resident Teaching Award Nominee, Massachusetts General Hospital
  3. 2009 Travel Award, American Thoracic Society International Conference
  4. 2009 Fellows Asthma Conference Delegate, American College of Chest Physicians
  5. 2009 6th Annual Respiratory Disease Young Investigators’ Forum
  6. 2009 Loan Repayment Program Recipient, NIH
  7. 2009 Biomedical Research Fellowship, The Hartwell Foundation

 

Board Certification:

  • Internal Medicine
  • Pulmonary Disease
  • Critical Care Medicine

To schedule an appointment with Dr. Alexander, contact 858-642-3541

To contact Dr. Alexander: lcrotty@ucsd.edu