Division of Pulmonary, Critical Care & Sleep Medicine

Douglas J. Conrad, M.D.

Professor of Clinical Medicine

Director, Adult Cystic Fibrosis Clinic



  1. Diseases of the airways
  2. Asthma
  3. Cystic Fibrosis
  4. Diffuse bronchiecstasis



Response of airway epithelium to various stimuli particularly involved with inflammation. Focus specifically on the regulations of protein expression of CFTR and the lipid per oxidating enzyme 15-lipoxygenase is under investigation using transgenic mouse models of asthma and pseudomanias aeruginosa pneumonia


  1. Bradding P, Redington AE, Djukanovic , Conrad DJ, and Holgate ST.  15-lipoxygenase immunoreactivity in normal and asthmatic airways. Am J Respir Crit Care Med. 1995;151:1201-1204.
  2. Kritzik MR, Ziober AF, Dicharry S, Conrad DJ, Sigal E. Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. Biochim Biophys Acta. 1997;1352(3):267-81.
  3. Resnikoff JR, Conrad DJ. Recent advances in the understanding and treatment of cystic fibrosisCurrent Opinion in Pulmonary Medicine, 1998;4(3):130-4.
  4. Conrad DJ. The arachidonate 12/15-Lipoxygenases. A review of tissue expression and biological function. Clin Rev Allergy Immun 1999;17(1-2):17-89.
  5. Huang JT, Welsh JS, Ricote M, Kelly C, Binder C, Willson TM, Kelly C, Witzum JL, Funk C, Conrad DJ, Glass C. Interleukin-4-dependent production of PPAR-g ligands in macrophages by 12/15-lipoxygenase. Nature 1999; 400(6742):378-82.
  6. Conrad DJ.  The arachidonate 12/15 lipoxygenases. A review of tissue expression and biologic function. Clin Rev Allergy Immunol. 1999 Spring-Summer;17(1-2):71-89. Review.
  7. Conrad DJ,  Lu M.  Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription.  Am J Respir Cell Mol Biol. 2000 Feb;22(2):226-34.
  8. Wang AC, Dai X, Luu B, Conrad DJ.  Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation. Am J Respir Cell Mol Biol. 2001 Jun;24(6):688-93.
  9. Conrad DJ, Stenbit AE, Zettner EM, Wick, I, Eckhardt C, LHardiman G. Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population. Pharmacogenetics and Genomics 2008; 18:1095-1102.

PubMed listings of Publications

Board Certified:

  •  Internal Medicine
  •  Pulmonary Medicine

San Diego Magazine's "Top Doc" in Pulmonary Disease.

UCSD Adult Cystic Fibrosis Clinic

To schedule an appointment at the CF Clinic, call 858-657-7073.

Dr. Conrad can be reached directly at: dconrad@ucsd.edu