Division of Pulmonary, Critical Care & Sleep Medicine

Naveen Gupta, M.D.

Assistant Clinical Professor

 

CLINICAL INTERESTS:

1.  Sepsis
2.  Pneumonia
3.  Acute Respiratory Distress Syndrome
4.  Interstitial Lung Disease

 

INVESTIGATIVE INTERESTS:

My research focuses on understanding the therapeutic and mechanistic effects of bone marrow derived mesenchymal stem cells (MSCs) in experimental models of bacterial pneumonia and sepsis.  My current work is centered on determining the role of specific receptors (toll like receptors and protease activated receptors) on MSC function and using those findings to enhance the therapeutic effect of MSCs. 

 

SELECTED PUBLICATIONS:

    1.   Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA.  Human mesenchymal stem cells reduce mortality and bacteremia in gram negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.  Am J Physiol Lung Cell Mol Physiol 302: L1003-13, 2012 (PMID: 22427530)

    *2.  Gupta N, Krasnodembskaya A, Mouded M, Tan X, Serikov V, Matthay MA.  Mesenchymal stem cells enhance survival and bacterial clearance in murine E. coli pneumonia.  Thorax 67: 533-39, 2012 (PMID: 22250097).

    3.   Lee JS, Su X, Rackley C, Matthay MA, Gupta N.  Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.  Anat Rec 294: 165-172, 2011 (PMID: 21157927)

    4.   Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA.  Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial protein LL-37.  Stem Cells 28: 2229-2238, 2010 (PMID: 20945332)

    *5.  Lee JW, Fang X, Gupta N, Serikov V, Matthay MA.  Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex-vivo perfused human lung. Proc Natl Acad Sci USA 106: 16357-16362, 2009 (PMID: 19721001)

    6.   Lee JW, Gupta N, Serikov V, Matthay MA.  Potential application of mesenchymal stem cells in acute lung injury.  Expert Opin Biol Ther 9: 1259-1270, 2009 (PMID: 19691441) 

    7.   Su X, Looney MR, Gupta N, Matthay MA.  Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.  Am J Physiol Lung Cell Mol Physiol 297: L1-5, 2009 (PMID: 19411309)

    *8.  Gupta N, Su X, Popov B, Serikov V, Matthay MA.  Intrapulmonary Delivery of Bone Marrow Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-induced Acute Lung Injury in Mice.  J Immunol 179: 1855-1863, 2007 (PMID: 17641052)

    9.   Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA.  Activation of the α7 nAChR Reduces Acid-Induced Acute Lung Injury in Mice and Rats.  Am J Respir Cell Mol Biol 37: 186-192, 2007 (PMID: 17431097)

    10. Popov B,, Serikov V,  Petrov NS , Izusova TV , Gupta N, Matthay MA.  Lung Epithelial Cells A549 Induce Endodermal Differentiation in Mouse Mesenchymal BM Stem Cells by a Paracrine Mechanism.  Tissue Eng 13: 2441-2450, 2007 (PMID: 17630877)

    11. Serikov V, Popov B, Mikhailov VM, Gupta N, Matthay MA.  Evidence of Temporary Epithelial Repopulation by BM-Derived Cells in Airways Following Napthalene Injury in Mice.  Anat Rec 290: 1033-1045, 2007  (PMID: 17661377)

    12.       Gupta N and Matthay MA.  Sepsis and Stretch:  Synergistic Effects on Alveolar Epithelial Cell Death?  Crit Care Med 34:1846-7, 2006 (PMID: 16714999)

    SELECTED ABSTRACTS:

  1. *Sinha RK, *Burnier L, *Gupta N, Xu X, Kuprianov S, Martin G, Mosnier LO, Griffin JH. Novel R41Q-PAR1-Modified mice enable proof-of-concept studies for in vivo mechanisms of action for thrombin (IIa) and activated protein C (APC).  Blood (American Society of Hematology), 2014.
  2. Gupta N, Sinha RK, Xu X, Griffin JH.  R41Q-PAR1 Mutation Eliminates the Therapeutic Capacity of Bone Marrow Derived Mesenchymal Stem Cells in Murine E. coli Pneumonia. (submitted, American Thoracic Society), 2015.
  3. BOARD CERTIFICATION:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine