Division of Pulmonary, Critical Care & Sleep Medicine

Samir Makani, M.D.

Associate Clinical Professor

Director, Interventional Pulmonology and Bronchoscopy

Associate Program Director, PCCM Fellowship



  1. Advanced Diagnostic Bronchoscopy: Endobronchial Ultrasound (EBUS); Electromagnetic Navigational Bronchoscopy (Biopsy and Fiducial placement); Narrow Band Imaging (NBI)
  2. Therapeutic Bronchoscopy: Rigid Bronchoscopy; Airway Stents (Metallic, Silastic, and Hybrid) Insertion and Removal; Balloon and Mechanical Airway Dilatation; Laser Bronchoscopy (Nd:YAG); Electrocautery; Argon Plasma Coagulation (APC); Cryotherapy; Endobronchial Brachytherapy; Photodynamic Therapy(PDT); Foreign Body Removal; Whole Lung Lavage (Single and Bilateral); Endobronchial Management of Bronchopleural Fistula; Bronchial Thermoplasty
  3. Pleural Diseases: Thoracic Ultrasound; Thoracentesis (Diagnostic and Therapeutic); Closed Pleural Biopsy; Thoracostomy (Chest Tubes) with Pleurodesis; Indwelling Pleural Catheters (PleurX); Medical Thoracoscopy (Diagnostic and Therapeutic with Pleurodesis)



  1. Complex Central Airways Disease
  2. Lung Cancer



  1. S Makani et al “Biochemical and molecular basis of Thimerosal-induced apoptosis in T  cells: a major role of mitochondrial pathway.” Genes and Immunity 2002 Aug; 3(5):270-8
  2. Garcia et al “The Chain of Survival: Is It Time for a Fifth Link?” 54. Annals of Emergency Medicine. 46(3) Supplement:S17, September 2005.
  3. Wagner SA, Makani SS, Laber DA “Rituximab Induced Interstitial Lung Disease.” Blood (ASH Annual Meeting Abstracts) 2005 106: Abstract 4768
  4. Jen KY, Jain VV, Makani S, Finn PW “Immunomodulation of allergic responses by targeting costimulatory molecules.” Curr Opin Allergy Clin Immunol. 2006 Dec;6(6):489-94
  5. Jen KY, Campo M, He H, Makani SS, Velasco G, Rothstein DM, Perkins DL, Finn PW “CD45RB Ligation Inhibits Allergic Pulmonary Inflammation by Inducing CTLA4 Transcription.” J Immunol. 2007 Sep 15;179(6):4212-8
  6. SS Makani, V Test “Pulmonary Sclerosing Hemangioma Presenting as an Enlarging Pulmonary Mass” Chest 2007 - Am College of Chest Physicians (Oral Presentation)
  7. Makani S, Jen KY, Finn PW “New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses.” Curr Mol Med. 2008 Aug; 8(5):359-64
  8. Makani SS, Ray CD, Simoff MJ “Nonsurgical Correction of Specific Tracheal Stenosis:Pseudoglottic Stenosis” Tri-State Thoracic Conference Sep 2008 (Oral Presentation)
  9. Makani SS et al “Training Opportunities in Traditional Transbronchial Needle Aspiration (TBNA) Remains Unaffected with the Addition of Endobronchial Ultrasound Guided – TBNA” – American Thoracic Society -  2009 (Poster Discussion)
  10. Nakajima T, Suarez CJ, Lin KW, Jen KY, Schnitzer JE, Makani SS, Parker N, Perkins DL, Finn PW. “T cell pathways involving CTLA4 contribute to a model of acute lung  injury” J Immunol. 2010 May 15;184(10):5835-41


Board Certification:

  • Internal Medicine
  • Pulmonary Disease
  • Critical Care Medicine

UCSD Interventional Pulmonology Unit

To make an appointment, contact Stephanie Sombon at 619-543-5840

To contact Dr. Makani: smakani@ucsd.edu