Division of Pulmonary & Critical Care Medicine

Atul Malhotra, MD

Professor of Medicine
Division Chief, Pulmonary and Critical Care Medicine
Director of Sleep Medicine
Kenneth M. Moser Professor, Department of Medicine

INVESTIGATIVE INTERESTS:

The pathogenesis of sleep apnea
The metabolic/cardiovascular complications of sleep disorders
Mechanical ventilation in acute respiratory distress syndrome

ORIGINAL RESEARCH PUBLICATIONS:

  1. Schwartz D, Maroo A, Malhotra A, Kesselman H.  Negative pressure pulmonary hemorrhage.  Chest 1999; 115(4): 1194-8. PMID: 10208229.
  2. Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP.  Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.  J Appl Physiol 2000; 88(4):1346-54. PMID: 10749829.
  3. Malhotra A, Fogel R, Edwards J, Shea SA, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea. Am J Respir Crit Care Med 2000; 161(5):1746-9. PMID: 10806181.
  4. Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000; 162(3): 1058-62. PMID: 10988130.
  5. Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP.  Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender. Am J Respir Crit Care Med 2000; 162(5):1627-32. PMID: 11069787.
  6. Pillar G, Malhotra A, Fogel, R, Beauregard J, Slamowitz, D, Shea SA and White DP.  Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.  J Appl Physiol 2000; 89(4): 1275-82. PMID: 11007559.
  7. Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP.  Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.  J Clin Endocrinol Metab 2001; 86(3):1175-80. PMID: 11238505.
  8. Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, White DP. Upper airway collapsibility: measurements and sleep effects.  Chest 2001; 120(1):156-61. PMID: 11451832.
  9. Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP.  Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.  Respir Physiol 2001; 127(1):  23-38. PMID: 11445198.
  10. Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM.  The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation.  Eur Respir J 2001; 17(6): 1258-66. PMID: 11491174.
  11. Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP.  Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control. Am J Respir Crit Care Med 2001; 164(11): 2025-30. PMID: 11739130.
  12. Malhotra A, Pillar G, Fogel R, Edwards J, Ayas N, Akahoshi T, Hess D, White DP.  Pharyngeal pressure and flow effects on genioglossus activation in normal subjects Am J Respir Crit Care Med 2002; 165(1):71-7. PMID: 11779733.
  13. Fisher D, Pillar G, Malhotra A, Peled N, Lavie P.  Long-term follow-up of untreated patients with sleep apnea syndrome.  Respir Med 2002; 96(5): 337-43. PMID: 12113384.
  14. Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP.  Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.  Am J Respir Crit Care Med 2002; 165(7): 945-9. PMID: 11934719.
  15. Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ.  Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury.  Am J Physiol Lung Cell Mol Physiol 2002; 283(3): L585-95. PMID: 12169578.
  16. Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G.  Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms. Pediatrics 2002; 110(6): e74. PMID: 12456941.
  17. Malhotra A, Huang Y, Fogel RB, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP.  The male predisposition to pharyngeal collapse:  importance of airway length.  Am J Respir Crit Care Med 2002; 166(10):1388-95. PMID: 12421747.
  18. Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP.  Respiratory system loop gain in normal men and women measured with proportional-assist ventilation. J Appl Physiol 2003; 94(1):205-12. PMID: 12391042.
  19. Ayas N, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu F.  A prospective study of sleep duration and coronary heart disease in women.  Arch Intern Med 2003; 163(2): 205-9. PMID: 12546611.
  20. Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N.  Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus. J Pediatr 2003; 142(2):163-8. PMID: 12584538.
  21. Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT.  Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.  Arch Intern Med 2003;163(5): 565-71. PMID: 12622603.
  22. Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A.  Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.  J Appl Physiol 2003; 94(5): 1875-82. PMID: 12533492.
  23. Malhotra A, Muse V, Mark E.  Case records of the Massachusetts General Hospital.  Weekly clinicopathological exercise Case 12-2003: An 82-year-old man with dyspnea and pulmonary abnormalities.  New Engl J Med 2003; 348(16): 1574-85. PMID: 12700378.
  24. Fogel RB, Trinder J, Malhotra A, Stanchina M, Edwards JK, Schory KE, White DP.  Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.  J Physiol (Lond) 2003; 550(3):899-910. PMID: 12807995 PMCID: 2343065.
  25. Stanchina ML, Malhotra A, Fogel RB, Trinder J, Edwards JK, Schory K, White, DP.  The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.  Sleep 2003; 26(7):851-6.  PMID: 14655919.
  26. Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J.  Control of upper airway muscle activity in younger versus older men during sleep onset.  J Physiol (Lond) 2003; 553(2): 533-44. PMID: 12963804 PMCID: PMC2343562.
  27. Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP.  Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.  Sleep 2004; 27(2): 249-53. PMID: 15124718.
  28. Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A.  The role of open-lung biopsy in ARDS. Chest 2004; 125(1):197-202. PMID: 14718441.
  29. Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP.  Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.  Sleep 2004; 27(5):923-33. PMID: 15453551.
  30. Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP.  Postural effects on pharyngeal protective reflex mechanisms. Sleep 2004; 27(6):1105-12. PMID: 15532204.
  31. Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP.  The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (Lond) 2004; 558(3): 993-1004. PMID: 15218069 PMCID: PMC1665031.
  32. Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.  Sleep 2004; 27(7): 1394-403. PMID: 15586793.
  33. Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.  Am J Respir Crit Care Med 2004; 170(11): 1225-32. PMID: 15317668.
  34. Jordan AS, Wellman DA, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP.  Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.  J Appl Physiol 2005; 99(5): 2020-7. PMID: 15994243.
  35. Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ.  The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol (Lond) 2005; 564(2):549-62. PMID: 15695240 PMCID: PMC1464430.
  36. Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP.  Treatment adherence and outcomes in flexible vs. standard continuous positive airway pressure therapy. Chest 2005; 127(6):2085-93. PMID: 15947324 PMCID: PMC2287195.
  37. Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A.  Interferon-gamma 1b therapy in idiopathic pulmonary fibrosis:  a meta-analysis.  Chest 2005; 128:203-6. PMID: 16002936
  38. Huang Y, White DP, Malhotra A.  The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway.  Chest 2005; 128(3):1324-30. PMID: PMC16162725.
  39. Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CRR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB.  Paradoxical responses to positive end-expiratory pressure in patients with airway obstructive during controlled ventilation.  Crit Care Med 2005; 33(7):1519-28. PMID: 16003057 PMCID: PMC2287196.
  40. Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan A, Schory K, White DP.  Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.  Am J Respir Crit Care Med 2005; 172(1):114-7. PMID: 15817803. PMCID: 2718445.
  41. Huang Y, Malhotra A, White DP.  Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.   J Appl Physiol 2005; 99(3):1138-48. PMID: 1138-1148.
  42. Yinon D, Lowenstein L, Suraya S, Belooseski R, Zmora O, Malhotra A, Pillar G.  Pre-eclampsia is associated with sleep disordered breathing and endothelial dysfunction.  Eur Respir J 2006; 27(2):328-33. PMID: 16452588.
  43. Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP.  Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med 2006; 119(1): 72 e9-14. PMID: 16431197. PMCID: 2287192.
  44. Pittman SD, Pillar G, Berry R, Malhotra A, MacDonald MM, White DP.  Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.  Sleep and Breathing 2006; 10(3): 123-131. PMID: 16586136.
  45. Talmor D, Sarge T, O’Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH.  Esophageal and transpulmonary pressures in acute respiratory failure.  Crit Care Med 2006; 34(5):1389-94. PMID: 16540960. PMCID: 2278169.  (received invited editorial)
  46. Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep 2006; 29(4):470-7. PMID: 16676780.
  47. Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung protective ventilation in acute respiratory distress syndrome.  Respir Care 2006; 51(5):497-502. PMID: 16638159.
  48. Cho M, Malhotra A, Karmpoliotis D, Harris RS, Wain J, Patel SR.  Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome.  Ann Thorac Surg 2006; 82(1): 261-266. PMID: 16798226.
  49. Heinzer R, Stanchina M, Malhotra A, Jordan AS, Patel SR, Lo Y, Wellman A, Schory K, Dover L, White DP.  Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea. Thorax 2006; 61(5):435-9. PMID: 16490766.  PMCID: 2111199.
  50. Patel SR, Malhotra A, Gottlieb D, White DP, Hu FB.  Correlates of long sleep duration.  Sleep 2006; 29(7): 881-889. PMID: 16895254.
  51. Patel SR, Malhotra A, White DP, Gottlieb D, Hu FB.  Association between reduced sleep and weight gain in women.  Am J Epi 2006; 164(10): 947-954. PMID: 16914506.
  52. Nguyen TN, Badjatia N, Malhotra A, Gibbons F, Qureshi MM, Greenberg SA.  Factors predicting extubation success in patients with Guillain-Barré syndrome.  Neurocrit Care. 2006; 5(3): 230-4. PMID: 17290095.
  53. Karmpaliotis D., Kirtane AJ, Ruisi C, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D.  Diagnostic and prognostic utility of Brain Natriuretic Peptide in subjects admitted to the intensive care unit with hypoxic respiratory failure due to non-cardiogenic and cardiogenic pulmonary edema. Chest 2007; 131(4): 964-971. PMID: 17426196. PMCID: 2278171.
  54. Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP.  Chemical control stability in the elderly.  J Physiol (Lond) 2007; 581(1): 291-8. PMID: 17317747. PMCID: 2075232.
  55. Ronen O, Malhotra A, Pillar G.  The influence of gender and age on upper airway length during development.  Pediatrics 2007; 120(4): e1028-34. PMID: 17908723 PMCID: 2278168. 
  56. Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman DA, Lo Y, White DP and Malhotra A. The Influence of aging on pharyngeal collapsibility during sleep, Chest 2007; 131(6): 1702-1709. PMID: 17413053. PMCID: 2278166.
  57. Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea. Laryngoscope. 2007; 117(4): 648-653. PMID: 17415135.
  58. Chamberlin NL, Eikermann M, Fassbender P, White DP, and Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol (Lond) 2007; 579(2): 515-26. PMID: 17185342. PMCID: 2075396.
  59. Lo Y, Jordan A, Malhotra A, Wellman A, Heinzer R, Eikermann M, Schory K, Dover L, White DP.  The influence of wakefulness on pharyngeal airway muscle activity. Thorax 2007; 62(9): 799-805. PMID: 17389755. PMCID: 2117303. 
  60. Jordan AS, Wellman DA, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A and White DP.  Mechanisms used to restore ventilation  after partial upper airway collapse during sleep in humans.  Thorax 2007; 62(10): 861-867. PMID: 17412778. PMCID: 2094262.
  61. Pierce R, White DP, Malhotra A, Edwards J, Kleverlaan D, Palmer LJ, Trinder J.  Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea. Eur Respir J 2007; 30(2): 345-53. PMID: 17459896.
  62. Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP, Buxton A.  The impact of cardiac resynchronization therapy on obstructive sleep apnea in heart failure patients: a pilot study. Chest 2007; 132(2): 433-439. PMID: 17573498. PMCID: 2287194. 
  63. Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, White DP, and Chamberlin NL.  Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology 2007; 107(4): 621-629. PMID: 17893459.
  64. Talmor D, Sarge T, Legedza DA, O’Donnell CR, Ritz R, Loring SH, Malhotra A.  Cytokine release following recruitment maneuvers. Chest 2007; 132(5): 1434-1439. PMID: 17925413. PMCID: 2628458.
  65. Caramez MP, Miyoski E, Harris RS,  Kacmarek R, Malhotra A.  Gas exchange impairment induced by open suctioning in ARDS: Impact of permissive hypercapnia. Crit Care Med 2008; 36(2): 560-564. PMID: 18091534.
  66. Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, White DP, Chamberlin N. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing.  Anesthesiology 2008;108(5): 897-906. PMID: 18431126.
  67. Macdonald M, Fang J, Pittman S, White DP, Malhotra A.  The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta blockers. J Clin Sleep Med 2008; 4(1):38-42. (received invited editorial) PMID: 18350960. PMCID: 2276820.
  68. Heinzer R, White DP, Malhotra A, Lo Y, Dover L, Stevenson K, Jordan A.  Effect of expiratory positive airway pressure on sleep disordered breathing. Sleep 2008; 31(3):429-32. PMID: 18363320. PMCID: 2276743.
  69. Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J.  Discharge patterns of human genioglossus motor units during sleep onset. Sleep 2008; 31(4): 525-533. PMID: 18457240. PMCID: 2279758.
  70. Jia S, Malhotra A, Saeed M, Mark R, Talmor D.  Risk factors for acute respiratory distress syndrome in patients mechanically ventilated.  Chest 2008; 133(4): 853-61. PMID: 18263691. PMCID: 2628459.
  71. Heinzer R, White DP, Jordan AS, Lo Y, Dover L, Stevenson K, Malhotra A.  Trazodone increases arousal threshold in obstructive sleep apnoea.  Eur Respir J 2008; 31(6): 1308-1312. PMID: 18256066. PMCID: 2732198.
  72. Segal Y, Malhotra A, Pillar G.  Upper airway length may be associated with the severity of obstructive sleep apnea syndrome. Sleep & Breathing 2008; 12(4):311-6.
  73. Elinoff J, Talmor D, Subramanian B, Karmpaliotis D, Goldberger A, Malhotra A.  Effects of mechanical ventilation on the electrocardiogram in adults. Lung 2008; 186(4): 219-223. PMID: 18478291.
  74. Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL.  Neostigmine but not Sugaammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth 2008; 101(3):344-9. PMID: 18559352.
  75. Owens R, Hess D, Venegas J, Malhotra A, Harris RS.  Effect of the chest wall on pressure-volume curve analysis of ARDS lungs.  Crit Care Med 2008; 36(11): 2980-5. PMID: 18824918.
  76. Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP.  Effect of oxygen in obstructive sleep apnea: Role of loop gain.  Respir Physiol Neurobiol 2008; 31;162(2):144-51. PMID: 18577470.
  77. Talmor D, Sarge T, Malhotra A, O’Donnell C, Ritz R, Loring SH.  Mechanical ventilation guided by esophageal pressure in acute lung injury.  New Engl J Med 2008; 359(20): 2095-2104. PMID: 19001507 (received invited editorial)
  78. Yim Yeh S, Doupis J, Rahangdale S, Horr S, Malhotra A, Veves A.  Total serum bilirubin does not affect vascular reactivity in patients with diabetes.  Vasc Med 2009; 14(2):129-136. PMID: 19366819. PMCID: 2729815
  79. Eckert D, Malhotra A, Lo Y, White DP, Jordan AS. Genioglossus muscle activity during REM sleep on CPAP in men and women with and without obstructive sleep apnea.  Chest 2009; 135(4):957-64. PMID: 19118266
  80. Jordan AS, White DP, Lo Y, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A.  Airway dilator muscle activity and lung volume during stable breathing in OSA.  Sleep 2009; 32(3):361-368. PMID: 19294956, PMCID: PMC2647790
  81. Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS.  A comparison of methods to identify open-lung PEEP.  Intens Care Med 2009; 35(4):740-7. PMID 19183951
  82. Griesdale D, de Souza R, van Dam R, Heyland DK, Cook D, Malhotra A, Dhaliwal R, Talmor D, Chittock D, Finfer S.  Intensive insulin therapy and mortality in the critically ill: A meta-Analysis updated with the NICE-SUGAR data.  Can Med Assoc J 2009; 180(8):821-7. PMID: 19318387. PMCID: PMC2665940 (received invited editorial)
  83. Fassbender P, Geldner G, Blobner M, Hofmockel R, Rex C, Gautam S, Malhotra A, and Eikermann M.  Clinical predictors of duration of action of long-term administered Cisatracurium and Rocuronium. Am J Crit Care 2009; 18(5): 439-445. PMID 19723864.
  84. Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL.  Pentobarbital Dose-dependently Increases Respiratory Genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats. Anesthesiology 2009; 110(6): 1327-1334. PMID 19417601.
  85. Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L.  Association of lipid levels during gestation with pre-eclampsia and gestational diabetes mellitus: a population-based study. Am J Obstet Gynecol 2009; 201: 482 e1-9. PMID: 19631920.
  86. Buckley J, Addrizzo-Harris DJ, Clay AS, Curtis JR, Kotloff RM, Lorin SM, Murin S, Sessler CN, Rogers PL, Rosen MJ, Spevetz A, King TE,  Malhotra A, Parsons P. Multi-society task force recommendations of competencies in pulmonary and critical care medicine. Am J Respir Crit Care Med 2009; 180: 290-295. PMID: 19661252.
  87. Wilkinson V, Malhotra A, Jordan AS, Worsnop C, Nicholas C, Saboisky J, Butler J, Gandevia S, White DP, Trinder J. Discharge patterns of human genioglossus motor units during arousal from sleep. Sleep 2010; 33(3): 379-387. PMID 20337197. PMCID: PMC2831433.
  88. Owens R, Malhotra A, Eckert D, White DP, Jordan A, The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol 2010; 108(2):445-51. PMID: 19940097.
  89. Loring SH, O’donnell C, Behazin N, Malhotra A, Sarge T, Ritz R, Talmor, D. Esophageal pressures in acute lung injury – do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics and lung stress. J Appl Physiol 2010; 108(3): 515-522. PMID: 20019160. PMCID: PMC2838644.
  90. Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS,  Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J 2010; 36(3):569-76. PMID: 20032012
  91. Kezirian E, Malhotra A, Goldberg A, White DP. Changes in OSA severity, biomarkers, and quality of life after multilevel surgery. Laryngoscope 2010; 120(7):1481-8. PMID: 20564750.
  92. Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med 2010; 6(4): 315-321. PMID 20726278. PMCID: PMC2919660.
  93. Yim Yeh S, Rahangdale S, Nguyen A, Jordan AS, Novack V, Veves A, Malhotra A. Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function. Sleep 2010; 33(9): 1177-1183. PMID 20857864. PMCID: PMC2938858
  94. Campana L, Owens R, Clifford G, Pittman S, White DP, Malhotra A. Phase rectified signal averaging as a sensitive index of autonomic changes with aging.  J Appl Physiol 2010; 108(6): 1668-1673. PMID: 20339014. PMCID: PMC2886688
  95. Eckert DJ, Saboisky JP, Jordan AS, White DP, Malhotra A. A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure. J Appl Physiol 2010; 108:1619-24. PMID: 20378702. PMCID: PMC2886693.
  96. Kezirian E, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg A. Interrater reliability of drug-induced sleep endoscopy. Arch Otolaryngol Head Neck Surg 2010;136(4):393-7. PMID: 20403857.
  97. Nemati S, Malhotra A, Clifford GD. Data fusion for improved respiratory rate estimation. EURASIP J Adv Signal Process 2010; 2010:926305.PMID: 20806056.  PMCID: PMC2929127.
  98. Peer A, Lorber A, Suraiya S, Malhotra A, Pillar G. The occurrence of Cheyne-Stokes respiration in congestive heart failure: the effect of age. Front Psychiatry 2010; 1:133. PMID: 21423443. PMCID: PMC3059641
  99. Nicholas CL, Bei B, Worsnop C, Malhotra A, Jordan AS, Saboisky JP, Chan JK, Duckworth E, White DP, Trinder J. Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep 2010; 33(11): 1529-1538. PMID 21102995. PMCID: PMC2954703
  100. Jordan AS, White DP, Owens R, Eckert D, Rahangdale S, Yim-Yeh S, Malhotra A. The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse. J Appl Physiol 2010; 109(2): 469-475. PMID: 20507968. PMCID: PMC2928593.
  101. Saboisky JP, Jordan AS, Eckert DJ, White DP, Trinder JA, Nicholas CL, Gautam S, Malhotra A. Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol. 2010; 109(6): 1939-1949. PMID: 20947713.
  102. Scheer F, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise and their interaction on cardiovascular function. P Natl Acad Sci 2010; 107(47): 20541-20546. PMID: 21059915. PMCID: PMC2996667.
  103. Doupis J, Rahangdale S, Gnardellis C, Pena SE, Malhotra A, Veves A. Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines and growth factors. Obesity 2011; 19(4):729-35. PMID: 20829804.
  104. Liu C, Cao Y, Malhotra A, Ling L. Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats. Respir Physiol Neurobiol 2011; 175(1): 29-36. PMID: 20833276. PMCID: PMC3005083.
  105. Nemati S, Abdala O, Bazan V, Yim Yeh S, Malhotra A, Clifford G. A non-parametric surrogate-based test of significance for T-Wave alternans detection.IEEE Trans Biomed Eng 2011; 58:1356-64. PMID: 20409986. PMCID: PMC3062089.
  106. Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage 2011; 54(2):787-93 PMID: 20888921.
  107. Sundar S, Novack V, Jarvis K, Bender SP, Lerner A, Panzica P, Mahmood F, Malhotra A, Talmor DJ. Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. Anesthesiology 2011; 114(5): 1102-1110. PMID: 21430518.
  108. Sharma B, Feinsilver S, Owens R, Malhotra A, McSharry D, Karbowitz S. Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function. Lung 2011; 189(1):37-41. PMID: 21132554.
  109. Yim-Yeh, S, Rahangdale, S, Nguyen, A, Stevenson, K, Novack, V, Veves, A, Malhotra, A. Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus. Obesity 2011; 19(1): 17-22. PMID: 20523303.
  110. Rahangdale S, Yim Yeh S, Novack V, Stevenson K, Barnard M, Furman M, Frelinger AL, Michaelson AD, Malhotra A. The influence of intermittent hypoxemia on platelet activation in obese obstructive sleep apnea patients. J Clin Sleep Med 2011; 7(2):172-8. PMID: 21509332. PMCID: PMC3077345 (received invited editorial)
  111. Mostafiz W, Dalci O, Sutherland K, Malhotra A, Srinivasan V, Darendeliler M, Cistulli P. Influence of oral dimensions on mandibular advancement splint treatment outcome in obstructive sleep apnea. Chest 2011; 139(6): 1331-1339. PMID: 21292761.
  112. Hedner J, White DP, Malhotra A, Herscovici S, Pittman SD, Zou D, Grote L, and Pillar, G. Sleep staging based on autonomic signals – a multi-center validation study. J Clin Sleep Med 2011; 7(3): 301-306. PMID:  21677901. PMCID: PMC3113970.
  113. Nemati S, Malhotra A, Clifford GD. T-wave alternans patterns during sleep in healthy, cardiac disease and sleep apnea patients. J Electrocardiol 2011; 44(2):126-30. PMID: 21163493. PMCID: PMC3062089
  114. Campana L, Clifford G, Trinder J, Pittman S, Malhotra A. A possible method to predict response to non-pharmacological insomnia therapy. J Clin Sleep Med 2011; 7(4): 370-375. PMID: 21897773. PMCID: PMC3161769
  115. Ferreira J, Bensenor F, Rocha MJ Salge, J, Harris RS, Malhotra A, Kairalla RA, Kacmarek RM, Carvalho C. A sigmoid fit for Pressure-Volume curves of Idiopathic Pulmonary Fibrosis patients in mechanical ventilation: clinical implications. Clinics (Sao Paulo) 2011; 66(7): 1157-1163. PMID 21876967. PMCID: PMC3148457.
  116. Wellman A, Eckert DJ, Jordan AS, Edwards BA, Passaglia CL, Jackson AC, Gautam S, Owens RL, Malhotra A, White DP. A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol 2011; 110(6): 1627-1637. PMID: 21436459. PMCID: PMC3119134.
  117. Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. J Appl Physiol 2011; 111(1): 55-67. PMID: 21474696. PMCID: PMC3137535
  118. Mandelbaum T, Scott SJ, Lee J, Mark RG, Waikar SS, Malhotra A, Howell MD, Talmor DJ,  Outcome of critically ill patients with acute kidney injury using the AKIN criteria. Crit Care Med 2011; 39(12): 2659-64. PMID: 21765352. PMCID: PMC3213281.
  119. Bertisch SM, Schomer A, Kelly EE, Baloa LA, Hueser LE, Pittman SD, Malhotra A. Device-guided paced respiration as an adjunctive therapy for hypertension in obstructive sleep apnea: A pilot feasibility study". Appl Psychophys Biof 2011; 36(3): 173-179. PMID: 21523471.
  120. Varvarigou V, Dahabreh IJ, Malhotra A, Kales SN. A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis. Sleep 2011; 34(11): 1461-1468. (received invited editorial) PMID: 22043116.
  121. United States Critical Illness and Injury Trials Group-Lung Injury Prevention Study Investigators. Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med 2011; 183(4): 462-471. PMID: 20802164. PMCID: PMC3056224.
  122. Eckert DJ, Owens RL, Kehlmann GB, Wellman A, Rahangdale S, Yim-Yeh S, White DP, Malhotra A. Eszopiclone increases the respiratory arousal threshold and lowers the apnea/hypopnea index in obstructive sleep apnea patients with low arousal threshold. Clin Sci (Lond) 2011; 120(12): 505-514. PMID: 21269278.
  123. Batool S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle aged women. Hypertension, 2011; 58(5):791-6. PMID: 21986505. PMCID: PMC3221559 (received invited editorial).
  124. Eckert DJ, Lo Y, Saboisky J, Jordan AS, White DP, Malhotra A. Sensori-motor function of the upper airway muscles and respiratory sensory processing in untreated obstructive sleep apnea, J Appl Physiol 2011; 111(6): 1644-53. PMID: 21885797. PMCID: PMC3233889.
  125. Jordan AS, Eckert DJ, Wellman A, Malhotra A, White DP. Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med 2011; 184(10):1183-91. PMID: 21836132. PMCID: PMC3262022 (received invited editorial).
  126. Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, O'Donoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside PG, Tyler L, Antic NA, Worsnop CJ, Kezirian EJ, Hillman DR. Treating obstructive sleep apnea with hypoglossal nerve stimulation (Rapid Publication). Sleep 2011; 34(11): 1479-1486. PMID: 22043118, PMCID: PMC3198202 (received invited editorial).
  127. Genta PR, Eckert DJ, Gregorio MG, Danzi NJ, Moriya HT, Malhotra A, Lorenzi-Filho G. Critical closing pressure during midazolam induced sleep. J Appl Physiol 2011; 111(5):1315-22. PMID 21852408.
  128. Novack V, MacFayden J, Malhotra A, Almog Y, Glynn R, Ridker P. Statin therapy and incident pneumonia: An exploratory analysis from the randomized, placebo controlled JUPITER trial. Can Med Assoc J 2012; 184:E367-72. PMID: 22431901. PMCID: PMC3328541.
  129. Lee J, Nemati S, Silva I, Edwards BA, Butler JP, Malhotra A. Transfer entropy estimation and directional coupling change detection in biomedical time series. Biomed Eng Online 2012; 11:19. PMID: 22500692. PMCID: PMC3403001
  130. Nicholas CL, Jordan AS, Heckel L, Worsnop C, Bei B, Saboisky JP, Eckert DJ, White DP, Malhotra A, Trinder J. Discharge patterns of human tensor palatini motor nits during sleep onset. Sleep 2012; 35(5): 699-707. PMID: 22547896. PMCID: PMC3321429.
  131. Patel SR, Malhotra A, Hu F, Neuman M, Fawzi W. A prospective study of sleep duration and pneumonia risk in women. Sleep 2012; 35(1):97-101. PMID: 22215923. PMCID: PMC3242694 (received invited editorial).
  132. Campana LM, Owens RL, Suki B, Malhotra A. Measuring upper and lower airway resistance during sleep with the forced oscillation technique. Ann Biomed Eng 2012; 40(4):925-33 PMID: 22127514. PMCID: PMC3387574
  133. Balachandran J, Bakker J, Rahangdale S, Yim-Yeh S, Meitus J, Goldberger A, Malhotra A. Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements. Am J Cardiol 2012; 109(1):140-5. PMID: 21945139.
  134. Engelberts D, Malhotra A, Butler J, Topulos G, Loring SH, Kavanagh B. Relative effects of negative vs. positive pressure ventilation depend on applied conditions. Intens Care Med 2012; 38(5): 879-85 PMID: 22349427. PMCID: PMC3463870
  135. Powell ED, Gay PC, Ojile JM, Litinski M, Malhotra A. A pilot study assessing adherence to auto-bilevel following a poor initial encounter with CPAP. J Clin Sleep Med 2012; 8(1): 43-47. PMID: 22334808, PMCID: PMC3266339 (received invited editorial).
  136. Cao Y, Li C, McGuire M, Malhotra A, Ling L. Phasic respiratory modulation of pharyngeal collapsibility via neuromuscular mechanisms in rats. J Appl Physiol 2012; 112(5): 695-703. PMID: 22052868. PMCID: PMC3198201.
  137. Zhang C, Varvarigou V, Parks PD, Gautam S, Bueno AV, Malhotra A, Kales SN. Psychomotor vigilance testing of professional driver in the occupational health clinic: A potential objective screen for daytime sleepiness. J Occup Environ Med 2012; 54(3):296-302. PMID: 21826029. PMCID: PMC3415601
  138. Edwards BA, Sands SA, Eckert DJ, White DP, Butler JP, Owens RL, Malhotra A, Wellman A. Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnea. J Physiol (Lond) 2012; 590(5): 1199-211. PMID: 22219335 (received invited editorial).
  139. Awad K, Malhotra A, Barnett J, Quan S, Peppard P. Exercise is associated with a reduced incidence of sleep-disordered breathing. Am J Med 2012; 125(5):485-90 PMID: 224828. PMCID: PMC3339801
  140. Schwartz AR, Barnes M,  Hillman D, Malhotra A, Kezirian E, Smith PL, Hoegh T, Parrish D, Eastwood P. Acute upper airway responses to hypoglossal nerve stimulation during sleep in obstructive sleep apnea. Am J Respir Crit Care Med 2012; 185(4): 420-6. PMID: 22135343. PMCID: PMC3297092
  141. Djonlagic I, Saboisky J, Carusona A, Stickgold R, Malhotra A. Increased sleep fragmentation leads to impaired off-line consolidation of motor memories in humans. PLoS One 2012; 7(3):e34106. PMID: 22470524. PMCID: PMC3314699.
  142. Saboisky JP, Staschuk DW, Hamilton-Wright A, Carusona A, Campana L, Trinder J, Eckert DJ, Jordan AS, McSharry D, White DP, Nandedkar S, David WS, Malhotra A. Neurogenic changes in the upper airway of obstructive sleep apnea patients. Am J Respir Crit Care Med 2012; 185(3):322-329. PMCID: PMC3006403 (received invited editorial).
  143. Altinas N, Arslan E, Helvaci A, Malhotra A, Relationship between obstructive sleep apnoea severity index and left ventricular function and volume. Ann Saudi Med J 2012; 32(4): 384-390. PMID: 22705609.
  144. Owens RL, Edwards BE, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume. J Appl Physiol 2012, 113(5):691-9. PMID: 22628372 PMCID: PMC3472473 (received invited editorial).
  145. Owens RL, Campana LM, Hess L, Eckert DJ, Loring SH, Malhotra A. Sitting and supine esophageal pressures in overweight and obese subjects. Obesity 2012; 20(12):2354-60. PMID: 22695479 PMCID: PMC3443522.
  146. Awad K, Drescher AA, Malhotra A, Quan SF. Effects of exercise and nutritional intake on sleep architecture in adolescents. Sleep and Breathing 2012 Jan. 31 [epub ahead of print] PMID: 22331514. PMCID: PMC3417155.
  147. Scheer F, Morris C, Garcia Pierce J, Smales C, Kelly E, Malhotra A, Marks J, Shea, SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with β-Blockers; a randomized controlled trial. Sleep. 2012; 35(10):1395-402. PMID: 23024438 PMCID: PMC3443766 (received invited editorial)
  148. Edwards BA, Connolly, JG, Campana, LM, Sands, SA, Trinder, JA, White, DP, Wellman, A, Malhotra A. Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea. Sleep 2013, 36(2): 281-285.  PMID: 23372276 PMCID:PMC3543060
  149. Hayes S, Murray S, Castriotta R, Landrigan C, Malhotra A.  (Mis)Perceptions and interactions of sleep specialists and generalists: Obstacles to referrals to sleep specialists and the multidisciplinary team management of sleep disorders. Journal of Clinical Sleep Medicine 2012, 8(6): 633-642. PMID: 23243396 PMCID: PMC3501659
  150. Sharma B, Bakker JP, McSharry D, Desai A, Javaheri S, Malhotra A. Adaptive servo-ventilation for treatment of sleep-disordered breathing in heart failure: A systematic review and meta-analysis. Chest 2012, 142(5):1211-1221. PMID: 22722232 PMCID: PMC3494473
  151. Li Y, Mirzael F, O’Reilly E, Winkelman J, Malhotra A, Okereke O, Ascherio A, Gao X. Prospective study of restless legs syndrome and risk of depression in women. Am J Epi, 2012;176(4):279-88. PMID:22805376 PMCID: PMC3491969
  152. Nemati, S, Lehman, LW, Adams, RP, Malhotra, A, Discovering shared cardiovascular dynamics within a patient cohort, Conf Proc IEEE Eng Med Biol Soc. ; 2012:6526-6529. PMID: 23367424
  153. Montesi S, Edwards BA, Malhotra A, Bakker, JP. The effect of continuous positive airway pressure treatment on blood pressure: A systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med 2012; 8(5):587-96 PMID: 23066375. PMCID: PMC3459209
  154. Pulliam SJ, Weinstein DF, Malhotra A, Macklin EA, Berkowitz LR. Baseline sleep dysfunction among matriculating interns. J Graduate Medical Education 2012, 4(2): 202-208. PMID: 23730442
  155. Berger MB, Varbarigou V, Rielly A, Czeisler CA, Malhotra A, Kales SN. Employer-mandated sleep apnea screening and diagnosis in commercial Drivers. J Occup Environ Med, 2012, 54(8):1017-25. PMID: 22850349 PMCID: PMC3415601
  156. Baughman R, Malhotra A, Surdulescu V, Lower E. Armodafinil for sarcoidosis associated fatigue: Double blind, placebo controlled, cross over trial. J Pain Symptom Manage, 2013, 45(2): 159-169. PMID: 22917711
  157. Kahlon, S, Eurich, D, Padwal, R, Malhotra, A, Minhas-Sandhu, J, Marrie, T, Majumdar, SR, Obesity and outcomes in patients hospitalized with pneumonia, Clinical Microbiology and Infection, 2013, 19(8): 709-716. PMID: 22963453
  158. Chang, SY, Dabbagh, O, Gajic, O, Patrawalla, A, Elie, M, Talmor, D, Malhotra, A, Adesanya, A, Anderson, HL, Blum, JM, Park, PK, Gong, M, Contemporary ventilator management in patients with and at risk of ALI/ARDS, Respiratory Care 2013; 58(4):578–588. PMID: 22906363
  159. Shaikh, Z, Jaye, J, Ward, N, Malhotra, A, de Villa, M, Polkey, M, Mullen, M, Morrell, M, Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure, Chest, 2013, 143(1) 56-63. PMID: 22924163
  160. Sharma, B, Neilan, TG, Kwong, RY, Mandry, D, Owens, RL, McSharry, D, Bakker, JP, Malhotra, A, Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea, COPD. 2013; 10(1):4-10. PMID: 23272670 PMCID: PMC3679499
  161. Malhotra, A, Younes, M, Kuna, ST, Benca, R, Kushida, CA, Walsh, J, Hanlon, A, Staley, B, Pack, AI, Pien, G, Performance of an automated polysomnography scoring system versus computer-assisted manual scoring, Sleep 2013;36(4):573-582 PMID:23565003 PMCID: PMC3612255
  162. Kuna ST, Benca R, Kushida CA, Walsh J, Younes M, Staley B, Hanlon A, Pack AI, Pien GW, Malhotra A. Agreement in computer-assisted manual scoring of polysomnograms across sleep centers. Sleep 2013;36(4):583-589 PMID: 23565004 PMCID: PMC3612259
  163. McSharry, DG, Saboisky, JP, DeYoung, P, Matteis, P, Jordan, AS, Trinder, J, Smales, E, Hess, L, Guo, M, Malhotra, A, A mechanism for upper airway stability during slow wave sleep, Sleep 2013;36(4):555-563 PMID:23565001 PMCID: PMC3612252
  164. Mandelbaum, T, Lee, J, Scott, DJ, Mark, RG, Malhotra, A, Howell, MD, Talmor, D, Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med. 2013, 39(3): 414-419. PMID: 23223822
  165. Weiss, JP, Jumadilova, Z, Johnson, TM, Fitzgerald, MP, Carlsson, M, Matire, DL, Malhotra, A, Efficacy and safety of flexible-dose fesoterodine in men and women with overactive bladder symptoms, including nocturnal urinary urgency, J Urol. 2013; 189(4):1396-1401 PMID: 23159276 (received invited editorial).
  166. Lehman L, Saeed M, Talmor DJ, Mark R, Malhotra A. Methods of blood pressure measurement in the intensive care unit. Critical Care Medicine, 2013, 41(1):34-40. PMID: 23269127 PMCID: PMC3724452
  167. Campana, LM, Malhotra, A, Suki, B, Hess, L, Israel, E, Smales, E, DeYoung, P, Owens, RL,  The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma, Respir. Physiol. Neurobiol. 2013;185(2):304-12. PMID: 23041446 PMCID: PMC3529972
  168. Wellman, A, Edwards, BA, Sands, SA, Owens, RL, Nemati, S, Butler, J, Jackson, A, Malhotra, A, White, DP, A simplified method for determining phenotypic traits in patients with obstructive sleep apnea, J Appl Physiol. 2013; 114(7):911-22. PMID: 23349453 PMCID: PMC3633440
  169. Campana, L, Owens, RL, Suki, B, Butler, JP, Malhotra, A, Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma, Respir. Physiol. Neurobiol., 2013;186(3):290-295 PMID: 23473922 PMCID: PMC3659817
  170. Lehman, LH, Nemati, S, Adams, RP, Moody, G, Malhotra, A, Mark, RG, Tracking Progression of Patient State of Health in Critical Care Using Inferred Shared Dynamics in Physiological Time Series, IEEE and EMBC 2013; 2013:7072-7075. PMID: 24111374
  171. Stanchina, ML, Welicky, LM, Donat, W, Lee, D, Corrao, W, Malhotra, A, Impact of CPAP Use and Age on Mortality in Patients with Combined COPD and Obstructive Sleep Apnea: the Overlap Syndrome, Journal of Clinical Sleep Medicine 2013, 9(8): 767-772. PMID: 23946706.
  172. Li, Y, Wang, W, Winkelman, JW, Malhotra, A, Ma, J, Gao, X, Prospective study of restless legs syndrome and mortality among men, Neurology 2013; 81(1):52-9.  PMID 23761622. PMCID: PMC3770202
  173. Shaw, N, Goodwin, JL, Silva, GE, Hall, JE, Quan, S, Malhotra, A, Obstructive Sleep Apnea (OSA) in Preadolescent Girls is Associated with Delayed Breast Development Compared to Girls without OSA, Journal of Clinical Sleep Medicine 2013, 9(8): 813-818. PMID: 23946712
  174. Sligl WI, Hoang H, Eurich DT, Malhotra A, Marrie TJ, Majumdar SR.  Macrolide use in the treatment of critically ill patients with pneumonia: incidence, correlates, timing, and outcomes. Canadian Journal of Infectious Diseases and Medical Microbiology 2013. 24(4): e107-102. PMID: 24489569.
  175. Colrain, IM, Black, J, Siegel, LC, Bogan, RK, Becker, PM, Farid-Moayer, M, Goldberg, R, Lankford, DA, Goldberg, AN, Malhotra, A, A multi-center evaluation of oral pressure therapy for the treatment of obstructive sleep apnea, Sleep Medicine 2013, 14(9): 830-837PMID: 23871259.
  176. Eckert, DJ, White, DP, Jordan, AS, Malhotra, A, Wellman, DA, Defining Phenotypic Causes of Obstructive Sleep Apnea: Identification of Novel Therapeutic Targets, Am. J. Respir. Crit. Care Med. 2013, 188(8): 996-1004 PMID: 23721582.
  177. Nemati, S, Edwards, BA, Lee, J, Pittman-Polletta, B, Malhotra, A, Respiration and Heart Rate Complexity: Effects of Age and Gender Assessed by Band-limited Transfer Entropy, Respiratory Physiology & Neurobiology 2013, 189(1): 27-33.  PMID: 23811194.
  178. Chervin, RD, Chesson, AL, Benca, RM, Greenough, GP, O’Hearn, DJ, Auckley, DH, Littner, M, Mullington, JM, Malhotra, A, Berry, RB, Malhotra, RK, Schulman, DA, Organization and structure for sleep medicine programs at academic institutions: Part 1 – Current Challenges, Sleep 2013, 36(6): 795-801. PMID: 23729918 PMCID: PMC3649818
  179. Chesson, AL, Chervin, RD, Benca, RM, Greenough, GP, O’Hearn, DJ, Auckley, DH, Littner, M, Mullington, JM, Malhotra, A, Berry, RB, Malhotra, RK, Schulman, DA, Organization and structure for sleep medicine programs at academic institutions: Part 2 – Goals and strategies to optimize patient care, education and discovery, Sleep 2013, 36(6): 803-811. PMID: 23729919
  180. Strohl KP, Brown DB, Collop N, George C, Grunstein R, Han F, Kline L, Malhotra A, Pack A, Phillips B, Rodenstein D, Schwab R, Weaver T, Wilson K; ATS Ad Hoc Committee on Sleep Apnea, Sleepiness, and Driving Risk in Noncommercial Drivers. An Official American Thoracic Society clinical practice guideline: sleep apnea, sleepiness, and driving risk in noncommercial drivers. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1259-66. PMID: 23725615
  181. Kaczmarek, E, Bakker, JP, Clarke, DN, Csizmadia, E, Kocher, O, Veves, A, Tecilazich, F, O’Donnell, CP, Ferran, C, Malhotra, A, Molecular biomarkers of vascular dysfunction in obstructive sleep apnea, PLoS ONE 8(7): e70559. doi:10.1371/journal.pone.0070559 PMID: 23923005 PMCID: PMC3726633
  182. Bakker, J, Balachandran, J, Tecilazich, F, Deyoung, P, Smales, E, Veves, A, Malhotra, A, A pilot study of the effects of bariatric surgery and CPAP treatment on vascular function in obese subjects with obstructive sleep apnea, Internal Medicine Journal 2013, 43(9): 993-998. PMID: 23800096 PMCID: PMC3769941
  183. Ginosar Y, Malhotra A, Schwartz E. High altitude, continuous positive airway pressure, and obstructive sleep apnea: subjective observations and objective data. High Alt Med Biol. 2013;14(2): 186-189. PMID: 23795742
  184. DeYoung, PN, Bakker, JP, Sands, SA, Batool-Anwar, S, Connolly, JG, Butler, JP, and Malhotra, A, Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea, Journal of Clinical Sleep Medicine 2013, 9(11): 1161-1164. PMID: 24235897
  185. Kezirian, E, Goding, GS, Malhotra, A, O’Donoghue, FJ, Zammit, G, Wheatley, JR, Catcheside, PG, Smith, PL, Schwartz, AR, Walsh, JH, Maddison, KJ, Claman, D, Huntley, T, Park, SY, Campbell, MC, Palme, CE, Iber, C, Eastwood, PR, Hillman, DR, Barnes, M, HGNS Improves OSA: 12 Month Outcomes, J. Sleep Res. 2014, 23(1): 77-83. PMID: 24033656
  186. Montesi, SB, Bakker, JP, Macdonald, M, Hueser, L, Pittman, S, White, DP, Malhotra, A, Air leak during CPAP titration as a risk factor for central apnea, Journal of Clinical Sleep Medicine, 2013, 9(11): 1187-1191. PMID: 24235901 (received invited editorial)
  187. Neilan, TG, Farhad, H, Dodson, J, Shah, RV, Abbasi, S, Bakker, JP, Michaud, G, Van der Geest, R, Blankstein, R, Steigner, M, John, R, Jerosch-Herold, M, Malhotra, A, Kwong, R, The Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation, Journal of the American Heart Association, 2013, 2(6): e000421. PMID: 24275628. 
  188. Schwab, RJ, Badr, SM, Epstein, LJ, Gay, PC, Gozal, D, Kohler, M, Levy, P, Malhotra, A, Phillips, BA, Rosen, IM, Strohl, KP, Strollo, PJ, Weaver, EM, Weaver, TE, ATS Subcommittee on CPAP Adherence Tracking Systems, An official american thoracic society statement: continuous positive airway pressure adherence tracking systems. The optimal monitoring strategies and outcome measures in adults. Am J Respir Crit Care Med. 2013;188(5):613-20. PMID: 23992588
  189. Teodorescu, M, Xie, A, Sorkness, CA, Robbins, J, Reeder, S, Gong, Y, Fedie, JE, Sexon, A, Miller, B, Huard, T, Hing, J, Bioty, N, Peterson, E, Kunselman, SJ, Chinchilli, VM, Soler, X, Ramsdell, J, Loredo, J, Israel, E, Eckert, DJ, Malhotra, A,  Effects of Inhaled Fluticasone on Upper Airway during Sleep and Wakefulness in Asthma – A Pilot Study, Journal of Clinical Sleep Medicine, in press.
  190. McSharry, DG, Saboisky, JP, DeYoung, P, Jordan, AS, Trinder, J, Smales, E, Hess, L, Malhotra, A,  Mechanisms of upper airway hypotonia during REM sleep, Sleep in press.
  191. Sarge, T, Loring, SH, Yitsak-Sade, M, Malhotra, A, Novack, V, Talmor, D, Raising PEEP in ARDS to achieve a positive transpulmonary pressure does not cause hemodynamic compromise, Intensive Care Medicine, 2014, 40(1): 126-128. PMID: 24126673
  192. Zhang, C, Li, Y, Malhotra, A, Nig, Y, Gao, X, Restless Legs Syndrome Status as A Predictor for Lower Physical Function, Neurology, in press.
  193. Smith, RS, Efron, B, Mah, CD, Malhotra, A, The impact of circadian misalignment on athletic performance in professional football players, Sleep 2013, 36(12): 1999-2001. PMID: 24293776.
  194. Eckert, DJ, Malhotra, A, Wellman, A, White, DP, Trazodone Increases the Respiratory Arousal Threshold in Obstructive Sleep Apnea Patients with a Low Arousal Threshold, SLEEP, in press.
  195. Djonlagic, I, Matteis, P, Carusona, A, Guo, M, Stickgold, R, Malhotra, A, Untreated Sleep-disordered Breathing: Links to Aging-related Decline in Sleep-Dependent Memory Consolidation, PLOS One, 2014; 91): e85918. PMID: 24489679.
  196. Beitler, JR, Shaefi, S, Montesi, SB, Devlin, A, Loring, SH, Talmor, D, Malhotra, A, Prone positioning for ARDS in the low tidal volume era, Intensive Care Medicine, in press. PMID: 24435203.
  197. Bakker, JP, Edwards, BA, Gautam, SP, Montesi, SB, Duran-Cantolla, J, Barandiaran, FA, Barbe, F, Sanchez-de-la-Torre, M, Malhotra, A, Blood pressure improvement with continuous positive airway pressure is independent of obstructive sleep apnea severity, Journal of Clinical Sleep Medicine in press.
  198. Shah RV, Abbasi SA, Farhad H, Dodson JA, Bakker JP, Michaud GF, van der Geest R, Blankstein R, Steigner M, John RM, Jerosch-Herold M, Malhotra A, Kwong RY, Neilan TG, Obesity and sleep apnea are independently associated with adverse left ventricular remodeling and clinical outcome in patients with atrial fibrillation and preserved ventricular function; American Journal of Cardiology, in press.
  199. Batool, S, Kales, SN, Patel, SR, Varvarigou, V, DeYoung, PN, Malhotra A, Obstructive Sleep Apnea and Psychomotor Vigilance Task Performance, Nature and Science of Sleep Medicine, in press.
  200. Owens RL, Edwards, BA, Sands, SA, Butler, JP, Eckert, DJ, White, DP, Malhotra, A, Wellman, DA, The classical Starling Resistor model often does not predict inspiratory airflow patterns in the human upper airway, Journal of Applied Physiology in press [epub ahead of print], PMID: 24458746
  201. Johnson, KD, Patel, SR, Baur, DM, Edens, E, Sherry, P, Malhotra, A, Kales, SN, Association of Sleep Habits with Accidents and Near Misses in United States Transportation Operators, JOEM in press.
  202. Edwards, BA, Wellman, A, Sands, SA, Owens, RL, Eckert, DJ, White, DP, Malhotra, A, Obstructive sleep apnea in older adults is a distinctly different physiological phenotype, Sleep, in press.

    Reviews Chapters and Editorials
  203. Malhotra A, Kradin R. The pulmonary immune response to asbestos.  In: Peters GA, Peters BJ, editors.  Asbestos and Cancer. Salem, NH: Butterworth Legal; 1997. p. 1-23.Schwartz D, Malhotra A, Fink M.  Cytopathic hypoxia in sepsis: an overview.  Sepsis 1999; 1:279-89.
  204. Ayas N, Malhotra A, Epstein L.  Alternative therapies for sleep apnea.  Drugs Today (Barc) 1999; 35(11): 811-21. PMID: 12973373.
  205. Malhotra A, Ayas N, Epstein L.  The art and science of continuous positive airway pressure therapy in obstructive sleep apnea.  Curr Opin Pulm Med 2000; 6(6): 490-495. PMID: 11100958.
  206. Pillar G, Malhotra A, Lavie P.  Post-traumatic stress disorder and sleep – what a nightmare! Sleep Med Rev 2000; 4(2): 183-200. PMID: 12531165.
  207. Schwartz D, Malhotra A, Fink M.  Cytopathic hypoxia in septic shock.  In: Malhotra, SK and Tuszynski J, editors.  Advances in Structural Biology. Stamford, CT:  Jai Press; 2000.  p. 65-82.
  208. Schwartz DR, Malhotra A, Fink MP.  Microcirculatory weak units – an alternative explanation.  Critical Care Medicine 2000; 28:3127-8.
  209. Sabatine M, Malhotra A, Systrom DM.  Pulmonary Disease. In: Sabatine, MD, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine.  Philadelphia: Lippincott Williams and Wilkins; 2000. p. 2-1-21.
  210. McCowen K, Malhotra A, Bistrian B.  Stress-induced hyperglycemia. Critical Care Clinics. 2001; 17(1):107-24. PMID: 11219223.
  211. Malhotra A, Schwartz DR, Ayas N, Stanchina M, White DP.  The treatment of oxygen-induced hypercarbia.  Lancet 2001; 357(9259):884-5. PMID: 11265981.
  212. Malhotra A, Schwartz D.  Lung Cancer.  In: Hess D, MacIntyre N, Mishoe S, Galvin WF, Adams AB, Saposnick AB, editors. Respiratory Care: Principles and Practice. Philadelphia: WB Saunders; 2002.  p. 1151-67
  213. Malhotra A, White DP.  The pathogenesis of obstructive sleep apnea.  In McNicholas W, Phillipson E, editors.  Breathing Disorders in Sleep. London: WB Saunders; 2002. p. 44-64.
  214. Malhotra A, White DP.  Obstructive sleep apnoea.  Lancet 2002; 360(9328): 237-45. PMID: 12133673.
  215. McCowen KC, Malhotra A.  The correlation between obstructive sleep apnea and low gonadotropin secretion in men.  Sleep Med 2003; 4:83-4.
  216. Malhotra A, Fogel R, White DP.  Disorders of excessive sleepiness. In: Neurological Therapeutics: Principles and Practice. Noseworthy JH, editor. London: Martin Dunitz Publishers; 2003. p. 1306-1310.
  217. Carden K and Malhotra A. The debate about gender differences in obstructive sleep apnea.  Sleep Med 2003; 4(6):485-7. PMID: 14607341.
  218. Bajwa E, Malhotra A, Thompson T.  Methods of monitoring shock. Seminars in Respiratory and Critical Care Medicine 2004; 25(6):629-644. PMID: 16088506.
  219. Stanchina M, Malhotra A, White DP.  An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep. In Crapo JD, Glassroth JL, Karlinsky JB, Talmadge EK, editors. Baum’s Textbook of Pulmonary Disease, 7th Ed. Philadelphia: Lippincott; 2004. p. 1425-1450.
  220. Bajwa E, Mouded M, Systrom DM, Malhotra A.  Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. 2nd Ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 2:1-2:22.
  221. Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A. Open-lung biopsy for ARDS Patients.  Chest 2004; 126:1003-4.
  222. Fogel RB, Malhotra A, White, DP.  Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.  Thorax 2004; 59(2): 159-163. PMID: 14760159. PMCID: 1746928.
  223. Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A.  Surgical stress in ARDS open-lung biopsy.  Chest 2004;126:1383-4
  224. Malhotra A, Berry R, White DP.  Central sleep apnea. In: Carney PR, Berry RB, Geyer J, editors. Clinical Sleep Disorders.  Philadelphia: Lippincott; 2005. p. 331-46.
  225. Ting L, Malhotra A.  Disorders of Sleep: an overview.  Prim Care 2005; 32(2):305-18. PMID: 15935187.
  226. Malhotra A, Jordan AS.  Surface tension and sleep apnea: a sticky business.  Sleep 2005; 28(4):392-3. PMID: 16172618.
  227. Kacmarek R and Malhotra A.  High frequency oscillatory ventilation: what large animal studies have taught us!  Critical Care Medicine 2005; 33(3S):S148-54. PMID: 15753721 PMCID: 2278170.
  228. Jordan A, Malhotra A.  Pharyngeal lumen: both length and size matter.  J Clin Sleep Med 2005; 1(3): 264-265. PMID: 17566186.
  229. Pillar G, Harder L, Malhotra A.  Trauma and post-traumatic stress disorder. In: Chang T, Vihtelic CM, Gold C, Lydic R, and Baghdoyan HA, editors.  Encyclopedia of Sleep Medicine.  New York: John Wiley & Sons; 2006: 857-66.
  230. Malhotra A, Jordan AS.  Did fat boy Joe need hormone replacement?  Sleep 2006; 29(1):16-8. PMID: 16453975.
  231. Malhotra A.  Intensive insulin in intensive care.  New Engl J Med, Received invited editorial 2006; 354(5):516-8. PMID: 16452564. PMCID: 2287193.
  232. Kacmarek RM, Villar J, Malhotra A.  Modes of mechanical ventilation.  In: Albert RK, Slutsky A, Ranieri M, Takala J, Torres A, editors.  Clinical Critical Care Medicine. Philadelphia: Elsevier Publishing Company; 2006. p. 109-120. 
  233. Kacmarek RM, Malhotra A.  Equipment required for home mechanical ventilation.  In: Tobin MJ, editors.  Principles and Practice of Mechanical Ventilation. 2nd Ed.  New York: McGraw Hill; 2006. p. 97-128
  234. Heinzer R., Jordan AS, Malhotra A.  Sleep Apnea Syndrome.  In: Khoo, M., editor.  Wiley Encyclopedia of Biomedical Engineering.  New York: John Wiley and Sons; 2006. p. 18-34.
  235. Yim S, Jordan AS, Malhotra A.  Obstructive sleep apnea, clinical presentation, diagnosis and treatment.  In: Randerath WJ, Sanner BM, Somers VK, editors.  Sleep Apnea – Current diagnosis and treatment.  Basel: Karger;  2006. 35:118-136.
  236. Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A.  Intensive insulin in the medical intensive care unit, New Engl J Med. 2006; 354: p. 2069-71.
  237. Malhotra A and Patel SR. Lung biopsy in ARDS: Is it worth the risk?  Critical Care 2006; 10(4): 160. PMID: 16941755. PMCID: 1750997.
  238. Yim S, Malhotra A, Veves A. Anti-oxidants and CVD in diabetes: Where do we stand now? Current Diabetes Reports 2007; 7:8-13. PMID: 17254512.
  239. Eckert D, Jordan A, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment, Chest 2007; 131(2):595-607. PMID: 17296668. PMCID: PMC2287191.
  240. Loring SH and Malhotra A. Inspiratory efforts during mechanical ventilation: is there risk of barotrauma? Chest 2007; 131(3):646-648. PMID: 17356075. PMCID: PMC2278167.
  241. Shochat T, Pillar G, Malhotra A. Aging and sleep, invited review. Int J Sleep Disorders 2007;1(3):92-101.
  242. Benson A, Bajwa E, Malhotra A.  Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Third edition. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 2:1-2:23.
  243. Yim S, Fredberg JJ, Malhotra A. CPAP for asthma: not a big stretch?  European Respiratory Journal 2007; 29(2):226-228. PMID: 17264319
  244. Eikermann M, Magder S, Malhotra A. Is brachial artery peak velocity variation ready for prime time? Chest 2007; 131:1279-1281. PMID: 17494778. PMCID: PMC2278172.
  245. Eikermann M, Chamberlin N, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: Don’t immobilize the diaphragm unnecessarily.  Crit Care Med 2007; 35(6):1634-1635. PMID 17522551.
  246. Malhotra A. Low Tidal Volume Ventilation in the acute respiratory distress syndrome. N Engl J Med 2007; 357:1113-1120. PMID: 17855672. PMCID: PMC2287190.
  247. Nguyen A, Yim S, Malhotra A,  Theories of OSA pathogenesis.  In: Obstructive Sleep Apnea: Pathophysiology, Comorbidities and Consequences,  two volume textbook 508 ages, Taylor and Francis (London, UK), Ed. Kushida, CA, 2007.
  248. Eckert D, Saboisky J, Jordan A, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea. J Clin Sleep Med 2007; 3(6):570-3. PMID 17993036. PMCID: PMC2045709.
  249. Chiche L, Forel JM, Papazian L, Asakura Y, Komatsu T, Busch T, Bercker S, Kaisers U, Malhotra A.  Low tidal volume ventilation. N Engl J Med 2007; 357: 2518-2520.
  250. Malhotra A, Kacmarek RM.  Mechanical ventilation.  In: Hagberg C, editor. Benumof’s airway management: principles and practice. Philadelphia: Lippincott Publishing Co; 2007. p. 1079-1122.
  251. Eikermann M and Malhotra A. Predictive value of stimulated muscle force assessment in critically ill patients, Editorial. Acta Anaesthesiol Scand. 2008; 52(1):1-2. PMID 18173429.
  252. Goodwin AJ, Bajwa EK, Malhotra A.  Minimally invasive cardiology.  In: Irwin RS, Cerra FB, Rippe JM, editors.  Irwin and Rippe’s Intensive Care Medicine, 6th Edition. Philadelphia: Lippincott Williams & Wilkin; 2008. p. 261-274.
  253. Eckert D and Malhotra A.  Pathophysiology of adult obstructive sleep apnea.  Proceedings of the American Thoracic Society 2008; 5(2):144-53. PMID: 18250206. PMCID: PMC2628457.
  254. Malhotra A and Hillman D.  Obesity and the lung: Obesity, respiration and intensive care. Thorax 2008; 63(10):925-931.  PMID: 18820119. PMCID: PMC2711075.
  255. Malhotra A, Bertisch S, and Wellman DA.  Complex apnea isn’t a real disease. J Clin Sleep Med invited Pro/Con 2008; 4(5): 406-408. PMID: 18853695. PMCID: PMC2576324.
  256. Owens R, Eckert D, Yeh S, Malhotra A. Upper airway function in the pathogenesis of obstructive sleep apnea: A review of the current literature.  Curr Opin Pulm Med invited review. 2008; 14(6):519-24. PMID: 18812828. PMCID: PMC 2697390.
  257. Yim Yeh S, Rahangdale S, Malhotra A. Metabolic syndrome, OSA and CPAP: A weighty issue. Chest 2008;134(4):675-676. editorial. PMID: 18842905.
  258. Owens R, Yim Yeh S, Malhotra A. CO Poisoning or CO Protection. Chest 2008; 134(5):895-6. editorial.  PMID: 18988771
  259. Rahangdale S, Campana L, Malhotra A.  Not so good vibrations, Sleep 2008;31(9):1204-05. PMID: 18788644, PMCID: PMC2542974.
  260. Rahangdale S, Yim Yeh S, Malhotra A,  Veves A. Therapeutic interventions and oxidative stress in diabetes. Frontiers in Bioscience 2009; 14:192-209. PMID: 19273063.
  261. Malhotra A and Loscalzo J. Cardiovascular complications of sleep disorders: An overview. Progress in Cardiovascular Diseases (Guest Editor A Malhotra) 2009; 51(4):279-84. PMID: 19110129. PMCID: PMC2722952.
  262. Eckert DJ, Malhotra A, Jordan AS.  Mechanisms of apnea.  Progress in Cardiovascular Diseases (A. Malhotra guest editor) 2009; 51(4):313-23. PMID: 19110133.
  263. Saboisky J, Chamberlin N, Malhotra A. Promising therapeutic targets in sleep apnea, invited review. Expert Opinion on Therapeutic Targets 2009; 13(7):795-809. PMID: 19530985. PMCID: PMC2729816.
  264. Atkeson A, Yim Yeh S, Malhotra A, Jelic S.  Endothelial function in obstructive sleep apnea.  Progress in Cardiovascular Diseases (Guest Editor A. Malhotra) 2009; 51(5):351-362.  PMID: 19249441.
  265. Talmor D, Malhotra A, Loring SH. Esophageal pressure in acute lung injury.  N Engl J Med 2009; 360:831-833.
  266. Loring SH, Garcia-Jacques M, Malhotra A.  Pulmonary characteristics in COPD and mechanisms of increased work of breathing.  J Appl Physiol 2009, 107(1): 309-314. PMID: 19359620. PMCID: PMC2711781.
  267. Campana L, Eckert D, Patel SR, Malhotra A. OSA Pathophysiology. Indian Journal of Medical Research 2010, 131: 176-187. PMID: 20308743 (invited review).
  268. Rahangdale S and Malhotra A. The arousal threshold in OSA. Frontiers in Neuroscience. E-book (vol. 3, issue 3), Theme: Sleep and Dreams. http://www.frontiersin.org/books/e_book__frontiers_in_neuroscie/33/all_books
  269. Owens R, Wellman A, Malhotra A. The chicken or egg debate in OSA pathogenesis: Comment on Loewen et al. "Determinants of ventilatory instability in Obstructive Sleep Apnea (OSA): Inherent or acquired?" Sleep 2009; 32(10): 1255-1256. PMID 19848354. PMCID: PMC2753803.
  270. Saboisky J, Eckert D, Malhotra A. Stable breathing through deeper sleeping. Thorax 2010; 65(2):95-6. PMID: 20147587 (received invited editorial).
  271. Owens R, Harris RS, Malhotra A. Is the way to man’s heart (and lung) through the abdomen? Critical Care 2009; 13(6): 199. PMID: 19909491. PMCID: PMC2811916 (received invited editorial).
  272. Goodwin A, Bajwa E, Malhotra A. Non-invasive cardiology. In: Irwin RS, Rippe JM, editors. Irwin and Rippe’s Intensive Care Medicine. 7th Edition. Philadelphia: Lippincott; 2012.  p. 245-257.
  273. Goodwin A, Bajwa E, Malhotra A. In: Irwin RS, Rippe JM, Lisbon A, Heard SO, editors. Irwin and Rippe’s Procedures, Techniques and Minimally Invasive Monitoring in Intensive Care Medicine. 5th edition. Philadelphia: Lippincott; 2012. p. 276-288.
  274. Sharma B, Owens R, Malhotra A. Sleep in congestive heart failure. Medical Clinics of North America 2010; 94(3): 447- 464.  PMID 20451026.
  275. Gladysheva K, Malhotra A, Owens R. Influencing the decline of lung function in COPD: Use of pharmacotherapy. International Journal of COPD 2010; 5: 153-164. PMID: 20631815. PMCID: PMC2898088.
  276. Thomas Z, Bandali F, McCowen K, Malhotra A. Drug-induced endocrine disorders in the intensive care unit. Crit Care Med 2010; 38(6S): S219-230. PMID: 20502175.
  277. Edwards B, Driscoll D, Ali A, Jordan AS, Trinder J, Malhotra A. “Aging and sleep: physiology and pathophysiology”, Seminars in Respiratory and Critical Care Medicine 2010; 31(5): 618-633. PMID: 20941662.
  278. Eastwood PR, Malhotra A, Palmer LJ, Kezirian EJ, Horner RL, Ip MS, Thurnheer R, Antic NA, Hillman DR. Obstructive sleep apnoea: From pathogenesis to treatment: Current controversies and future directions. Respirology 2010; 15(4):587-95. PMID: 20136736.
  279. Malhotra A, and Owens R. What is central sleep apnea? Respiratory Care 2010; 55(9):1168-78. PMID: 20799999. (Invited contribution from Expert Roundtable).
  280. Roca, D, Eckert, D, Yim Yeh, S, Malhotra, A, Control of Breathing, in Atlas of Clinical Sleep Medicine, editors: Kryger, Avidan, Berry. 1st Edition. Philadelphia: Elsevier, 2010; 45-52.
  281. Owens R, and Malhotra A. Sleep disordered breathing and chronic obstructive pulmonary disease: The overlap syndrome. Respiratory Care 2010; 55(10): 1333-1346. PMID 20875160 (Invited contribution from Expert Roundtable).
  282. McSharry D, Eckert D, Malhotra A. Central sleep apnoea. In: McNicholas WT and Bonsignore MR, editors. Sleep Apnoea. Sheffield, UK: European Respiratory Society; 2010. p.381-395. (chapter 22 in European Respiratory Monographs, volume 50; see table of contents at http://erm.ersjournals.com/content/ermsa/1.toc)
  283. Djonlagic I and Malhotra A. Risk of stroke from sleep apnea in men and women. Expert Rev Neurother 2010; 10(8):1267-71. PMID: 20662752.
  284. Sharma B, McSharry D, Malhotra A. Sleep disordered breathing in patients with heart failure: Pathophysiology and management. Curr Treat Options Cardiovasc Med 2011; 13(6):506-16. PMID: 21894522.
  285. Shih JL and Malhotra A. Could vitamins be helpful to sleep apnea patients? Chest 2011; 139(2): 237-238. PMID: 21285049 (received invited editorial).
  286. Owens RL, Wellman A, Malhotra A. Which OSA patients might respond to nasal valves? J Clin Sleep Med 2011; 7(1): 23-24. PMID: 21344055 PMCID: PMC3041631.
  287. Kohli P, Balachandran J, Malhotra A. Obstructive sleep apnea and the risk for cardiovascular disease. Current Atherosclerosis Reports 2011; 13(2): 138-46 PMID: 21253882.
  288. Strohl KP, Butler JP, Malhotra A. Mechanical properties of the upper airway. Compr Physiol 2012, 2:1-20. PMID: 23723026 PMCID: PMC3770742
  289. Malhotra A, Butler J, Wellman A, The pharyngeal airway: Is bigger really better? Chest 2012; 141(6): 1372-1375. PMID: 22670014.
  290. Owens RL, Edwards BA, Malhotra A, Wellman A. Expiratory resistance increases end-expiratory lung volume during sleep. Am J Respir Crit Care Med 2012; 185(8): e10-1. PMID: 22505761 PMCID: PMC3360575.
  291. Malhotra A, Disorders of Control of breathing. In Golden L, Schafer AI, editors. Goldman’s Cecil Medicine. 24th Edition. Philadelphia: Elsevier; 2012. p. 527-531.
  292. Kohli P, Schwab R, Malhotra A. Management of sleep disordered breathing. In: Avidan AY and Zee PC, editors. Handbook of Sleep Medicine Philadelphia: Lippincott Williams & Wilkins; 2012. p. 127-147.
  293. Bakker JP, Sharma B, Malhotra A. Obstructive sleep apnea: the elephant in the cardiovascular room. Chest 2012; 141(3): 580-581. PMID:22396556.
  294. Malhotra A. Future of sleep apnea therapy using a mechanistic approach. Sleep Science 2012; 5:33-37.
  295. Montesi S, Bajwa E, Malhotra A. Biomarkers of sleep apnea, Chest 2012, 142(1): 239-245. PMID: 22796846   PMID: 22796846 PMCID: PMC3418859
  296. Malhotra A. Cardiovascular consequences of sleep disorders. Sleep Science 2012, 5(2): 68-72.
  297. Rice M, Hibbert K, Malhotra A. Pulmonary Disease. In: Sabatine MS, editor. Pocket Medicine. 4th Edition. Philadelphia: Lippincott, Williams & Wilkins; 2011.
  298. Awad K, Raju D, Malhotra A. Sleep Medicine. In: Greer D, editor. Pocket Neurology, 2010.
  299. Malhotra A and Strollo P. Selecting the Research Question. AASM Handbook on Research, in press.
  300. Velasquez A, Rahangdale S, Malhotra A. CPAP effect on cardiovascular disease. Sleep Medicine Clinics, in press.
  301. Pillar G, White DP, Malhotra A. Age-related changes in the pharyngeal structure and function in sleep apnea and normal subjects.  In: Pandi-Perumal SR, Monti JM, and Monjan A, editors. Principles and Practice of Geriatric Sleep Medicine. Cambridge: Cambridge University Press, 2010. p 75-86.
  302. Hibbert KA, Rice M, Malhotra A. Obesity and the acute respiratory distress syndrome. Chest 2012, 142(3):785-90. PMID: 22948584 PMCID: PMC3435141
  303. Zhang, C, Berger, M, Malhotra, A, Kales, SN, Portable diagnostic devices for identifying obstructive sleep apnea among commercial motor vehicle drivers: Considerations and unanswered questions, Sleep, 2012, 35(11): 1481-1489. PMID: 23115397. PMCID: PMC3466795 (received invited editorial)
  304. Ahluwalia, N, Owens, RL, Badr, MS, and Malhotra, A, Sleep and control of Breathing in Kushida, C (Ed.) The Encyclopedia of Sleep, Waltham, MA: Elsevier, 2013, 1:525-532.
  305. Mayson, D, Awad, K, Neilan, T, Malhotra, A, Obstructive sleep apnea in the elderly: Extent of the problem, Current Cardiovascular Risk Reports, in press.
  306. Rice M, Hibbert K, Malhotra A. Acid Base Balance. In: Urman R, Frendl G, editors.  Pocket ICU. Philadelphia: Lippincott, Williams & Wilkins; 2013.
  307. Butler, JP, Owens, RL, Malhotra, A, Wellman, A, CrossTalk opposing view: The human upper airway during sleep does not behave like a Starling resistor. J Physiol. (London) 2013 May 1; 591(Pt 9):2233-4. PMID: 23740880
  308. Butler JP, Owens RL, Malhotra A, Wellman A. Rebuttal from James P. Butler, Robert L. Owens, Atul Malhotra and Andrew Wellman. J Physiol. 2013 May 1;591(Pt 9):2237.  PMID: 23740882
  309. Jordan, AS, McSharry, D, Malhotra, A, Seminar: Adult Obstructive Sleep Apnoea, Lancet, 2013.  pii: S0140-6736(13) 60734-5, invited review,  PMID: 23910433
  310. Sundar, E and Malhotra, A, Unanswered questions in sleep and anesthesia, Sleep Medicine Clinics (Editor F. Chung, MD) 2013, Elsevier (Philadelphia, PA) 8(1): 165-176.
  311. Bakker, JP, Montesi, S, Malhotra, A, Obstructive sleep apnoea: new associations and approaches., Lancet Respiratory Medicine, 2013 Mar;1(1):e15-6. PMID: 24321811
  312. Beitler, JR, Hubmayr, RD, Malhotra, A, CrossTalk opposing view: There is not added benefit to providing permissive hypercapnia in the treatment of ARDS. J Physiol. (London) 2013 Jun 1; 591(Pt 11):2767-9. PMID: 23729791 PMCID: PMC3690680.
  313. Beitler JR, Hubmayr RD, Malhotra A. Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra. J Physiol. (London) 2013 Jun 1; 591(Pt 11):2773. PMID: 23729793 PMCID:PMC3690682
  314. Kohli, P, Sarmiento, K, Malhotra, A, Update in Sleep medicine, Am J Respir Crit Care Med. 2013; 187(10):1056-60. PMID: 23675714
  315. Plataki, M, Sands, SA, Malhotra, A, Clinical consequences of altered chemoreflex control, Respir. Physiol. Neurobiol. 2013 May 13. S1569-9048. PMID: 23681082
  316. Malhotra, A and Drazen, JM, High Frequency Oscillation in Acute Respiratory Distress Syndrome, New England Journal of Medicine, 2013; 368(9):863-5. PMID: 23339640
  317. Zhang, C, Berger, M, Malhotra, A, Kales, S, Portable diagnostic devices and commercial motor vehicle drivers, Sleep 2013, 36(8): 1263-1264. PMID: 23904688
  318. Edwards, BA, Malhotra, A, Sands, SA, Adapting our approach to treatment-emergent central sleep apnea. Sleep 2013, 36(8): 1121-1122. PMID: 23904668 PMCID: PMC3700705
  319. Lower, E, Malhotra, A, Surdurlescu, V, Baughman, R, Sarcoidosis, fatigue and sleep apnea.  Chest 2013, 144(6): 1976-1977. PMID: 24297143.
  320. Horner, RL, Hughes, SW, Malhotra, A, State-Dependent and Reflex Drives to the Upper Airway Basic Physiology with Clinical Implications, Journal of Applied Physiology, in press. PMID:23970535
  321. Barbash, I, Hibbert, KA, Malhotra, A, Pulmonary in Sabatine, MS, editor. Pocket Medicine, Philadelphia: Lippincott, Williams & Wilkins, 2013, 2:1-2:23.
  322. Malhotra, A and Powell, F, Disorders of Control of breathing. In Golden L, Schafer AI, editors. Goldman’s Cecil Medicine. 25th Edition. Philadelphia: Elsevier, 2014; in press.
  323. Eckert, D, Roca, D, Yim Yeh, S, Malhotra, A, Control of Breathing, in Atlas of Clinical Sleep Medicine, editors: Kryger, Avidan, Berry. 2nd Edition. Philadelphia: Elsevier, 2014; 45-52.
  324. Orr, J, Edwards, BA, Malhotra, A, Elevated Loop Gain is Acquired in Obstructive Sleep Apnea (Pro/Con), J. Physiol. (London), in press.
  325. Roebuck, R, Monasterio, V, Gederi, E, Osipov, M, Behar, J, Malhotra, A, Penzel, T, Clifford, GD, A review of signal used in sleep analysis. Physiol Meas. 2014; 35(1):R1-R57. PMID: 24346125
  326. Eckert, DJ, White, DP, Jordan, AS, Malhotra, A, Wellman, A, Reply: Arousal threshold in obstructive sleep apnea, AJRCCM 2014, 189(3): 373-374. PMID: 24484350.
  327. Malhotra, A, Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea, New England Journal of Medicine, 2014, 370(2): 170-171. PMID: 24401056

Click for all of Dr. Malhotra's publications on PubMed.

BOARD CERTIFICATIONS:

  • Pulmonary Disease
  • Critical Care Medicine
  • Sleep Medicine

To contact Dr. Malhotra, please call Brenda Dixon: (858) 657-6485