Division of Pulmonary, Critical Care & Sleep Medicine

Timothy Rodwell, MD, PhD, MPH

Associate Professor

INVESTIGATIVE INTERESTS

Dr. Rodwell’s research is primarily focused on tuberculosis (TB) with an emphasis on the molecular epidemiology of drug resistance and development and implementation of rapid molecular diagnostics for TB and acute febrile syndromes. He is currently leading a large multinational study to develop and field test a novel, table-top platform for clinical diagnosis of XDR-TB (R01AI111435), and is Project Director of a CFAR study to demonstrate that quantifiable, phenotypic drug resistance to fluoroquinolone antibiotics can be reliably predicted by rapidly detectable mutations in Mycobacterium tuberculosis (Mtb). He is also a co-investigator on several NIH funded studies examining the functional significance of novel mutations in drug resistant Mtb genomes (R01AI105185), developing a point-of-care platforms for rapidly detecting drug-resistant strains of Tuberculosis (R44EB011274, R44 GM103053) and a clinical trial to demonstrate the effectiveness of mobile phone-based TB therapy monitoring (U01 AI116392).

SELECTED PUBLICATIONS

1.    Rodwell TC, Barnes RFW, Moore M, Strathdee SA, Raich A, Moser KS, Garfein RS. HIV–Tuberculosis coinfection in southern California: Evaluating disparities in disease burden. Am J Public Health. 2010;100(S1):S178-S85. PMCID: PMC2837460

2.    Rodwell TC, Kapasi AJ, Moore M, Milian-Suazo F, Harrise B, Guerrerod LP, Moser KS, Strathdee SA, Garfein RS. Tracing the origins of Mycobacterium bovis tuberculosis in humans in the United States to cattle in Mexico using spoligotyping. Int J Infect Dis. 2010;14S:e129–e35. PMCID: PMC2920372

3.    Georghiou SB, Magana M, Garfein RS, Catanzaro DG, Catanzaro A, Rodwell TC. Evaluation of Genetic Mutations Associated with Mycobacterium tuberculosis Resistance to Amikacin, Kanamycin and Capreomycin: A Systematic Review. PLoS ONE. 2012;7(3):e33275. PMCID: PMC3315572

4.    Rodwell TC, Kapasi A, Barnes RFW, Moser K. Factors Associated with Genotype Clustering of M. tuberculosis Isolates in an Ethnically Diverse Region of Southern California, United States. Infect, Genet Evol. 2012;12(8):1917-25. PMCID: PMC3723456

5.    Yen YF, Rodwell TC, Yen MY, Shih HC, Li LH, Garfein RS. DOT associated with reduced all-cause mortality among tuberculosis patients in Taipei, Taiwan, 2006- 2008. Int J Tuberc Lung Dis. 2012;16(2):178-84. PMCID: PMC3289585

6.    Bojorquez I, Barnes RF, Flood J, Lopez-Gatell H, Garfein RS, Backer CE, Alpuche C, Vinetz JM, Catanzaro A, Kato-Maeda M, Rodwell TC. Multidrug-resistant tuberculosis among patients in Baja California, Mexico, and Hispanic patients in California. Am J Public Health. 2013;103(7):1301-5. PMCID: PMC3682598

7.    Morris MD, Quezada L, Bhat P, Moser K, Smith J, Perez H, Laniado-Laborin R, Estrada-Guzman J, Rodwell TC. Social, economic, and psychological impacts of MDR-TB treatment in Tijuana, Mexico: a patient's perspective. The International Journal of Tuberculosis and Lung Disease. 2013;17(7):954-60. PMCID: PMC3769163

8.    Bennett RJ, Brodine S, Waalen J, Moser K, Rodwell TC. Prevalence and Treatment of Latent Tuberculosis Infection Among Newly Arrived Refugees in San Diego County, January 2010-October 2012. Am J Public Health. 2014;104(4):e95-e102. PMCID: PMC4025726

9.    Lin SY, Rodwell TC, Victor TC, Rider EC, Pham L, Catanzaro A, Desmond EP. Pyrosequencing for rapid detection of extensively drug-resistant Mycobacterium tuberculosis in clinical isolates and clinical specimens. J Clin Microbiol. 2014;52(2):475-82. PMCID: PMC3911348

10.  Rodwell TC, Valafar F, Douglas J, Qian L, Garfein RS, Chawla A, Torres J, Zadorozhny V, Soo Kim M, Hoshide M, Catanzaro D, Jackson L, Lin G, Desmond E, Rodrigues C, Eisenach K, Victor TC, Ismail N, Crudu V, Gle MT, Catanzaro A. Predicting Extensively Drug-resistant Tuberculosis (XDR-TB) Phenotypes with Genetic Mutations. J Clin Microbiol. 2014;52(3):781-9. PMCID: PMC3957771

11.  Ajbani K, Lin SY, Rodrigues C, Nguyen D, Arroyo F, Kaping J, Jackson L, Garfein RS, Catanzaro D, Eisenach K, Victor TC, Crudu V, Gler MT, Ismail N, Desmond E, Catanzaro A, Rodwell TC. Evaluation of pyrosequencing for detecting extensively drug-resistant Mycobacterium tuberculosis among clinical isolates from four high-burden countries. Antimicrob Agents Chemother. 2015;59(1):414-20. PMCID: PMC4291380

12.  Avalos E, Catanzaro D, Catanzaro A, Ganiats T, Brodine S, Alcaraz J, Rodwell T. Frequency and Geographic Distribution of gyrA and gyrB Mutations Associated with Fluoroquinolone Resistance in Clinical Mycobacterium Tuberculosis Isolates: A Systematic Review. PLoS One. 2015;10(3):e0120470. PMCID: PMC4376704

13.  Catanzaro A, Rodwell TC, Catanzaro DG, Garfein RS, Jackson RL, Seifert M, Georghiou SB, Trollip A, Groessl E, Hillery N, Crudu V, Victor TC, Rodrigues C, Lin GS, Valafar F, Desmond E, Eisenach K. Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis. PLoS One. 2015;10(8):e0136861. PMCID: PMC4556461

14.  Colman RE, Schupp JM, Hicks ND, Smith DE, Buchhagen JL, Valafar F, Crudu V, Romancenco E, Noroc E, Jackson L, Catanzaro DG, Rodwell TC, Catanzaro A, Keim P, Engelthaler DM. Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing. PLoS One. 2015;10(5):e0126626. PMCID: PMC4430321

15.  Garfein RS, Catanzaro D, Rodwell TC, Avelos E, Jackson L, Kaping J, Evasco H, Rodriques C, Crudu V, Lin G, Grossel E, Hillery N, Trollip A, Ganiats T, Eisenach KV, F., Channick J, Qian L, Catanzaro A. Phenotypic and genotypic diversity in a multinational sample of drug-resistant Mycobacerium tuberculosis isolates. Int J Tuberc Lung Dis. 2015;19(4):420-7. PMCID: PMC4494864

16.  Seifert M, Catanzaro D, Catanzaro A, Rodwell TC. Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review. PLoS One. 2015;10(3):e0119628. PMCID: PMC4370653

17.  Torres JN, Paul LV, Rodwell TC, Victor TC, Amallraja AM, Elghraoui A, Goodmanson AP, Ramirez-Busby SM, Chawla A, Zadorozhny V, Streicher EM, Sirgel FA, Catanzaro D, Rodrigues C, Gler MT, Crudu V, Catanzaro A, Valafar F. Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates. Emerg Microbes Infect. 2015;4(7):e42. PMCID: PMC4522615

Complete List of publications at My NCBI

http://www.ncbi.nlm.nih.gov/sites/myncbi/timothy.rodwell.1/bibliography/40764875/public/?sort=date&direction=ascending