Division of Pulmonary, Critical Care & Sleep Medicine

 

Xavier Soler, M.D., Ph.D.

Associate Professor of Medicine
Associate Director, Pulmonary Rehabilitation Program
Associate Director, Clinical Trials Center & Airway Research Center

 

AREAS OF INTEREST
Chronic Lung Disease: Pathophysiology of COPD and asthma. Pulmonary Rehabilitation and activity monitoring in chronic lung disorders. Sleep disorders affecting COPD. Hypoxemia in chronic lung disease. Imaging in chronic lung disease. Tobacco cessation. Public and medical education.

PEER-REVIEWED PUBLICATIONS

I. Original Articles
  1. Soler X, Malet A, de la Torre X. Chest pain, fever, persistent pulmonary nodules and poly-neuropathy in a 55-year-old man (clinic-pathologic conference). Med Clin (Barc) 2000; 115(4):151-7. PMID: 10996888
  2. García A, Prats MS, Ruiz-Manzano J, Perendreu J, Muchart J, Monsó J, Rosell J, Soler Tomas X, Morera J. Threatening hemoptysis. Results of treatment with arterial embolization. J Rev Clin Esp. 2001; (3):113-7. PMID: 11387818
  3. Roig J, Soler X, Domingo C, Celis G. Serological evidence of Legionella species infection in acute exacerbation of COPD. Eur Respir J 2002; 20:504-506. PMID: 12212988
  4. Soler Tomas X, Guma Uriel M, Ruiz Manzano J. Massive fatal hemoptysis due to tuberculosis. Ann Med Interna. 2002 Aug; 19(8):435-6. PMID: 12244795
  5. Soler X, Murio C, Heras J, Calero G, Pérez M, Morera J, Ruiz-Manzano J. Hábito tabáquico en pacientes con enfermedad pulmonar obstructiva crónica (EPOC). Estudio EPOTABAC. Prevención del Tabaquismo. 2008;10(3):95-101. PMID: 19406603
  6. Soler X, Sell R, Maestre J, Ruiz-Manzano. Bronchial rupture by an unusual mechanism of thoracic hyperextension. J Emerg Med. 2009; Apr 28. PMID: 19406603
  7. Morris TA, Marsh JJ, Magana MM, Liang NC, Soler X, DeSantis DJ, Ngo D, Woods VL. High Prevalence of Dysfibrinogenemia Among Patients with Chronic Thrombo-Embolic Pulmonary Hypertension. Blood. 2009; 114:1929-36 PMID: 19420351
  8. Loredo JS, Soler X, Bardwell W, Ancoli-Israel S, Dimsdale JE, Palinkas LA. Sleep health in U.S. Hispanic population. Sleep. 2010 Jul 1; 33(7):962-7. PMID: 20614856
  9. Soler X, Murio C, Pérez M, Calero G, Ruiz-Manzano J. Acute exacerbation of chronic obstructive pulmonary disease in primary care setting in Spain: the EPOCAP study. Ther Adv Respir Dis. 2010 Aug; 4(4):215-23.  PMID: 20920137
  10. Soler X, Hoh CK, Kerr KM, Test V, Marsh JJ, Morris TA. Single Photon Emission Computerized Tomography in Chronic Thromboembolic Pulmonary Hypertension. Single photon emission computed tomography in chronic thromboembolic pulmonary hypertension. Respirology. 2011 Jan; 16(1):131-7. PMID: 20920137
  11. Soler X, Kerr KM, Marsh JJ, Renner JW, Hoh CK, Morris TA. Pilot Study Comparing SPECT Perfusion Scintigraphy to CT Pulmonary Angiography in Chronic Thromboembolic Pulmonary Hypertension. Respirology. 2012 Jan; 17(1):180-4. doi: 10.1111/j.1440-1843.2011.02061.x PMID: 21899658
  12. Soler X, Diaz-Piedra C, Ries AL. Pulmonary Rehabilitation improves sleep quality in chronic lung disease. COPD. 2013 Apr; 10(2):156-63. PMID: 23514215
  13. Kinney GL, Black-Shinn JL, Wan ES, Make B, Regan E, Lutz S, Soler X, Silverman EK, Crapo J, Hokanson JE; the COPDGene Investigators. Pulmonary Function Reduction in Diabetes Mellitus with and without Chronic Obstructive Pulmonary Disease. Diabetes Care. 2013 Sep 11. PMID: 24026562
  14. Teodorescu M, Xie A, Sorkness CA, Robbins J, Reeder S, Gong Y, Fedie JE, Sexton A, Miller B, Huard T6, Hind J, Bioty N, Peterson E, Kunselman SJ, Chinchilli VM, Soler X, Ramsdell J, Loredo J, Israel E, Eckert DJ, Malhotra A. Effects of Inhaled Fluticasone on Upper Airway during Sleep and Wakefulness in Asthma: A Pilot Study. J Clin Sleep Med. 2014 Feb 15; 10(2):183-93. doi: 10.5664/jcsm.3450. 1. Bowler RP, Kim V, Regan E, Williams A, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo J, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath H, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJ, Wilson C, Wendt C, Wise RA; For the COPDGene investigators. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Jun 19. doi: 10.1378/chest.13-2946. PMID: 24945159
  15. Castaldi PJ, Dy J, Ross J, Chang Y, Washko GR, Curran-Everett D, Williams A, Lynch DA, Make BJ, Crapo JD, Bowler RP, Regan EA, Hokanson JE, Kinney GL, Han MK, Soler X, Ramsdell JW, Barr RG, Foreman M, van Beek E, Casaburi R, Criner GJ, Lutz SM, Rennard SI, Santorico S, Sciurba FC, DeMeo DL, Hersh CP, Silverman EK, Cho MH. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22. doi: 10.1136/thoraxjnl-2013-203601. PMID: 24563194.
  16. X Soler, C Diaz-Piedra, W Bardwell, S Ancoli-Israel, L Palinkas, J Dimsdale, J Loredo. Sleep Quality among Hispanics of Mexican Descent and Non-Hispanic Whites: Results from the Sleep Health and Knowledge in US Hispanics Study. Open Journal Respiratory Disease. 2013. May; 3: 97-106. http://dx.doi.org/10.4236/ojrd.2013.32015. DOI: 10.4236/ojrd.2013.32015
  17. Bowler RP, Kim V, Regan E, Williams AA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJ, Wilson C, Wendt C, Wise RA; COPDGene investigators. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct; 146(4):941-50. doi: 10.1378/chest.13-2946. PubMed. PMID: 24945159; PubMed Central PMCID: PMC4188150.
  18. Park SJ, Foreman MG, Demeo DL, Bhatt SP, Hansel NN, Wise RA, Soler X, Bowler RP. Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities, and CT metrics. Respirology. 2015 Jan; 20(1):108-14. doi: 10.1111/resp.12421. PMID: 25328036
  19. Smith LJ, Kalhan R, Wise RA, Sugar EA, Lima JJ, Irvin CG, Dozor AJ, Holbrook JT; American Lung Association Asthma Clinical Research Centers. Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial. JAMA. 2015 May 26; 313(20):2033-43. doi: 10.1001/jama.2015.5024. PubMed PMID: 26010632.
  20. Jaramillo JD, Wilson C, Stinson DJ, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald ML, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA; COPDGene Investigators. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015. May; 12(5):648-56. doi: 10.1513/AnnalsATS.201412-591OC. PubMed PMID: 25719895; PubMed Central PMCID: PMC4418341.
  21. Park SJ, Foreman MG, Demeo DL, Bhatt SP, Hansel NN, Wise RA, Soler X, Bowler RP. Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities and CT metrics. Respirology. 2015 Jan; 20(1):108-14. doi: 10.1111/resp.12421. Epub 2014 Oct 19. PubMed PMID: 25328036; PubMed Central PMCID: PMC4415502.
  22. Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL. High Prevalence of Obstructive Sleep Apnea in Patients with Moderate to Severe COPD. Ann Am Thorac Soc. 2015 Apr 14. [Epub ahead of print] PubMed PMID: 25871443.

II. INVITED ARTICALES, BOOK CHAPTERS

  1. Soler X. Corticosteroides orales en Neumologia. Editors Felipe Andreo and Luis Lores. Madrid (Spain). 2005. (Co-author).
  2. Soler X. Tomografía de emisión de positrones (SPECT) en la enfermedad pulmonar tromboembólica. Medicina Respiratoria. 2009; 2:15-24. (Invited review).
  3. Soler X. Actualización en la enfermedad tromboembólica venosa: Fisiopatología. Madrid (Spain). SEPAR FC; 2009: 1-14 (Invited review).
  4. Soler X. Co-morbidities Blog Series; Sleep Apnea and COPD; What Patients should know. COPD-Foundation. (Invited article). 2012.
  5. Soler X. Sarcoidosis. Manual of Clinical Problems in Pulmonary Medicine, Seventh Edition. Editors Timothy Morris, Judd Landberg and Andrew L. Ries. (Invited chapter). 2014. ISBN 978-1-4511-1658-8
  6. Soler X. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Pulmonary Hypertension and pulmonary rehabilitation section. Guidelines for the ATS/ERS statement on Pulmonary Rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):e13-64. doi: 10.1164/rccm.201309-1634ST.
  7. Liao S, Benzo R, Ries AL, and Soler X. Physical activity monitoring in patients with chronic obstructive pulmonary disease. J COPD F. 2014; 2(1): 155-165. doi: http://dx.doi.org/10.15326/jcopdf.2.1.2014. Review.
  8. Soler X, Ramsdell J. Anticholinergics/Antimuscarinic Drugs in Asthma. Curr Allergy Asthma Rep. 2014. 14:484. DOI 10.1007/s11882-014-0484-y. Invited Review.
  9. Jacono F, Soler X, Malhotra A. The ventilatory Control. In Grippi M, Elias J, Fishman J, et al. Fishman’s Pulmonary Diseases and Disorders, 5th ed. New York: McGraw-Hill, in press. Invited book chapter. (2015).
  10. Soler X, Ramsdell JW. Are Asthma and COPD a Continuum of the Same Disease? J Allergy Clin Immunol Pract. 2015 Jul-Aug; 3(4):489-95. doi: 10.1016/j.jaip.2015.05.030. PubMed PMID: 26164572. Invited Review.

ABSTRACT PUBLISHED AND/OR PRESENTED (2006-present)

  1. Murio C, Anzueto A, Vilà S, Soler JJ, Tirado G, Soler X, Miravitlles M. EPOCA COPD study: Estudio Internacional Observacional En Pacientes Con Epoc En Fase Estable Y Agudizada Via Internet. EPOCA. SEPAR. Valencia. 2006.
  2. Murio C, Soler X, Ruiz Manzano J. EPOTABAC COPD Study: Estudio EPOTABAC. Resultados SOCAP. Granollers 2006.
  3. Soler X, Murio C, Ruiz Manzano J. Tobacco dependence in COPD general population. EPOCAP Study. SOCAP. Granollers 2006.
  4. Soler X, Loredo J, Dimsdale JE. Differences in Smoking Risks Between Mexican Americans and non-Hispanic Whites. Society of Behaviour Medicine. San Diego. 2008.
  5. Soler X, Ancoli-Israel S, Dimsdale JE, Loredo JS. Sleep quality and depression among Hispanic of Mexican Descent and Non-Hispanic whites in San Diego County. SLEEP. Baltimore. 2008.
  6. Morris TA, Marsh JJ, Magaña MM, Chiles PG, Soler X, DeSantis DJ, Ngo D, Woods VL. Fibrinogen Mutations Are Common Among Patients with Chronic Thromboembolic Pulmonary Hypertension. ATS Toronto. 2008.
  7. Marsh JJ, Chiles PG, Soler X, DeSantis DJ, Woods VL, Morris TA. A Mutation Affecting the t-PA Binding Domain of Fibrinogen (Fibrinogen San Diego III) in Patients with Chronic Thromboembolic Pulmonary Hypertension. ATS Toronto. 2008.
  8. Soler X, Renner J, Hoh C, Morris TA. SPECT perfusion scanning and Computed Tomographic Pulmonary Angiography (CTPA) in Chronic Thromboembolic Pulmonary Hypertension. AJRCCM 2009; 179 (1): A3331.
  9. Soler X, Kerr KK, Kim NH, Channick R, Test V, Hoh C, Morris TA. Segments occluded in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) do not predict outcomes after surgery. AJRCCM 2009; 179 (1): A3332.
  10. Soler X, Bardwell WA, Ancoli-Israel S, Palinkas LA, Loredo JS. Ethnic differences in sleep quality, depression and anxiety. AJRCCM 2009; 179 (1): A2115
  11. Soler X, Bardwell WA, Ancoli-Israel S, Palinkas LA, Dimsdale JE, Loredo JS. Ethnic differences in insomnia and depression/anxiety in Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County. Sleep. Seattle. 2009.
  12. Soler X, Hoh CK, Kerr KM, Kim HS, Marsh JJ, Morris TA, Channick RN. Single Photon Emission Computerized Tomography (SPECT) in Pulmonary Arterial Hypertension. ATS. New Orleans. 2010. AJCCM 2010. A3401.
  13. X Soler, S Ancoli-Israel, JS Loredo, AL Ries. The Impact of Pulmonary Rehabilitation on Sleep Quality in COPD. Sleep and Breathing, Barcelona, 2011.
  14. X Soler, C Díaz-Piedra, TM Limberg, JS Loredo, S Ancoli-Israel, AL Ries. Effect of Pulmonary Rehabilitation on Sleep Outcomes and Quality of Life in in Chronic Lung Disease. AASM (SLEEP) International meeting. Minneapolis 2011.
  15. M. Teodorescu, A. Xie, C.A. Sorkness, J.E. Fedie, A. Sexton, B. Miller, T. Wirth, Y. Gong, D. Pegelow, J. Hind, J.A. Robbins, M. Jaleel, X. Soler, J. Ramsdell, J. Loredo, E. Israel, D.J. Eckert, J.A. Dempsey, A. Malhotra. Effects of Inhaled Fluticasone on Upper Airway Collapsibility during Sleep and on Tongue Function in Asthma Patients. ATS. Denver. 2011.
  16. C. Diaz-Piedra, X. Soler, A. Lui, C. Larsen, T. Limberg, A. Nunn, M. Correa, A. Ries. The Relationship of Sleep Quality and Quality of Life in Chronic Lung Disease. ATS. Denver. 2011.
  17. X Soler, A Lui, C Larsen, C Díaz-Piedra*, T Limberg, A Nunn, MCorrea, AL Ries. The Impact of Pulmonary Rehabilitation on Sleep Quality in Chronic Lung Disease. ATS. Denver. 2011.
  18. Jaramillo J, Wilson C, Make B, Foreman M, Han ML, Soler X, Lynch D, Hockanson JE, Crapo JD, Regan EA. Gender differences in bone mineral density in subjects with COPD: males at increased risk of osteoporosis. ATS, San Francisco. 2012.
  19. X. Soler, A. Yen, J.L. Black-Shinn, R. San Jose Estepar, J.E. Hokanson, J.W. Ramsdell, A. Ries, A. Malhotra. Upper Airway Dynamics In Patients With COPD And Concomitant Obstructive Sleep Apnea (OSA): A Pilot Study. ATS, Philadelphia. 2013.
  20. David J. De La Zerda, Ariel Go, Xavier Soler, Andrew Ries, and Frank Powell. ATS 2013. Ibuprofen Does Not Reverse Ventilatory Acclimatization To Chronic Hypoxia.
  21. Xavier Soler, Eduardo Gaio, Pamela DeYoung, Ann R. Elliott, Trina Limberg, Arianna Villa, Maria Baylon, Rusell Sison-Tojino, Anne Mohney, Erik Smales, Jose S. Loredo, Joe W. Ramsdell, Atul Malhotra, Andrew L. Ries. High Prevalence Of Obstructive Sleep Apnea In Patients With Moderate To Severe COPD. ATS 2014.
  22. Xavier Soler, Andrew Yen, Jennifer L. Black-Shinn, Raul San Jose Estepar, John E. Hokanson, Joe W. Ramsdell, Andrew Ries, and Atul Malhotra. Upper Airway Dynamics In Patients With COPD And Concomitant Obstructive Sleep Apnea (OSA): A Pilot Study. ATS. 2013
  23. Jennifer L. Black-Shinn, , Gregory L. Kinney, Russell P. Bowler, Sharon M. Lutz, Mark Aloia, Marci Sontag, Xavier Soler, Andrew Yen, Irene Swift, Gerard J. Criner, and John E. Hokanson. Obstructive Sleep Apnea Is Independently Related To Chronic Bronchitis But Not Functional Reduction Or Emphysema In The COPDGene Cohort. ATS. 2014
  24. Irene Swift, Rachna Tiwari, Maria Elena Vega, Daohia Yu, Xavi Soler, Frederik Jaffe, Gerard J. Criner, Samuel L. Krachman, and COPD Gene investigators. Effect Of Emphysema Severity On The Apnea-Hypopnea Index In Smokers With Obstructive Sleep Apnea. ATS. 2014
  25. Andrew Yen, Jennifer L. Black-Shinn, Raul San Jose Estepar, John E. Hokanson, Samuel L. Krachman, Andrew L. Ries, Joe W. Ramsdell, Atul Malhotra, Xavier Soler. Airway Dynamics On Computed Tomography (CT) In Patients With Chronic Obstructive Pulmonary Disease (COPD) And Concomitant Obstructive Sleep Apnea (OSA): A Pilot Study Of Tracheal Length. ATS 2014
  26. David J. De La Zerda, Eduardo Gaio, Andrew L. Ries, Xavier Soler, Frank L. Powell. Neuromuscular Drive And Ventilatory Response To Hypoxia. ATS 2014
  27. Jennifer L. Black-Shinn, Gregory L. Kinney, Russell P. Bowler, Sharon M. Lutz, Mark Aloia, Marci Sontag, Xavier Soler, Andrew Yen, Irene Swift, Gerard J. Criner, and John E. Hokanson. The Berlin Sleep Questionnaire Lacks Utility In A COPD Population. ATS 2014
  28. Erin R. Narewski, , Amanda Blackford, Parag Desai, Matthew R. Lammi, Anne Fuhlbrigge, Xavier Soler, Richard K. Albert, and Gerard J. Criner. Clinical Differences In COPD Patients With Mild-Moderate Hypoxemia At Rest +/- Exertion Vs. Those Normoxemic At Rest Who Desaturate Only With Exertion. ATS 2014.

 

UCSD Pulmonary Rehabilitation Program

 
Dr. Soler can be reached via e-mail: xsoler@ucsd.edu