Kim E. Barrett, PhD

Professor of Medicine Chair, Biomedical Sciences Graduate Program Vice Chair for Research, Department of Medicine

INVESTIGATIVE INTERESTS:

1. Mechanisms and regulation of epithelial ion transport
2. Pathophysiology of cystic fibrosis
3. Role of mast cells in allergic and inflammatory diseases

SELECTED PUBLICATIONS:

1. Barrett KE, Bigby TD. Involvement of arachidonic acid in the chloride secretory response of intestinalepithelial cells. Am J Physiol 1993;264:C446-52.
2. Vajanaphanich M, Schultz C, Rudolf MT, Wasserman M, Enyedi P, Craxton A, Shears SB, Tsien RY, Barrett KE, Traynor-Kaplan AE. Long-term upcoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4. Nature 1994;371:711-4.
3. Vajanaphanich M, Schultz C, Tsien RY, Traynor-Kaplan AE, Pandol SJ, Barrett KE. Cross-talk between calcium and cAMP-dependent intracellular signaling pathways: implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells. J Clin Invest 1995;96:386-93.
4. Ismailov II, Fuller CM, Berdiev BK, Shlyonsky VG, Benos DJ, Barrett KE. A biologic function for an "orphan" messenger: D-myo-inositol (3,4,5,6) tetrakisphosphate selectively blocks epithelial calcium-activated chloride channels. Proc Natl Acad Sci USA 1996;93:10505-9.
5. Uribe JM, Keely SJ, Traynor-Kaplan AE, Barrett KE. Phosphatidylinositol 3-kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion. J Biol Chem 1996;271:26588-95.
6. Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fiere J, Smith JR, Kagnoff MF. Role of intestinal epithelial cells in the host secretory response to infection by invasion bacteria: bacterial entry induces epithelial prostaglandin H synthase-2 expression, and prostaglandin E2 and F2 production. J Clin Invest 1997;100:296-309.
7. Myers C, Hogan P, Yao B, Koss M, Isenberg JL, Barrett KE. Inhibition of rabbit duodenal bicarbonate secretion by ulcerogenic agents: histamine-dependent and -independent effects. Gastroenterology 1998;114:527-35.
8. Barrett KE, Smitham J, Traynor-Kaplan AE, Uribe JM. Inhibition of Ca2+-dependent Cl- secretion in T84 cells: membrane target(s) of inhibition are agonist-specific. Am J Physiol 1998;274:C958-65.
9. Keely SJ, Uribe JM, Barrett KE: Carbachol stimulates transactivation of epidermal growth factor receptor and MAP kinase in T84 cells: implications for carbachol-stimulated chloride secretion. J Biol Chem 1998;273:27111-7.
10. Barrett KE. Positive and negative regulation of chloride secretion in T84 cells. Am J Physiol 1993;265:C859-68.
11. Barrett KE, Pearce FL. Mast cell heterogeneity. In Immunopharmacology of Mast Cells and Basophils, JC Foreman, ed. London: Academic Press. pp 29-42, 1993.
12. Barrett KE, Bigby TD. New roles for eicosanoids as regulators of epithelial function and growth. News in Physiol Sci 1995;10:153-9.
13. Uribe JM, Barrett KE. Non-mitogenic actions of growth factors: an integrated view of their role in intestinal physiology and pathophysiology. Gastroenterology 1997;112:255-68.
14. Barrett KE. Integrated regulation of intestinal epithelial transport: intercellular and intracellular pathways. 1996 Bowditch Lecture. Am J Physiol 1997;272:C1069-76.