Douglas J.Conrad, MD

Director, Adult Cystic Fibrosis Program Associate Professor of Medicine

CLINICAL INTERESTS:

1. Diseases of the airways
2. Asthma
3. Cystic Fibrosis

INVESTIGATIVE INTERESTS:

Response of airway epithelium to various stimuli particularly involved with inflammation. Focus specifically on the regulations of protein expression of CFTR and the lipid per oxidating enzyme 15-lipoxygenase is under investigation using transgenic mouse models of asthma and pseudomanias aeruginosa pneumonia.

SELEDCTED PUBLICATIONS:

1. Conrad DJ, Kuhn H, Mulkins M. Highland E, Sigal E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc Natl Acad Sci USA. 1992;89:217-21.
2. Sigal E, Sloan DL, Conrad DJ. Human 15-lipoxygenase: Induction by interleukin-4 and insights into positional specificity. J Lipid Med 1993;6(1-3):75-88.
3. Sigal E, Conrad DJ. Human 15-lipoxygenase: A potential effector molecule for interleukin-4. In Advances in prostaglandins, thromboxane and leukotriene research. Raven Press. Vol 22, pp, 309-16, 1994.
4. Bradding P, Redington AE, Djukanovic, Conrad DJ, Holgate ST. 15-lipoxygenase immunoreactivity in normal and asthmatic airways. Am J Respir Crit Care Med 1995;151:1201-4.
5. Kritzik MR, Ziober AF, Dicharry S, Conrad DJ, Sigal E. Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. Biochem Biophys Acta 1997;1352(3):267-81.
6. Resnikoff JR, Conrad DJ. Recent advances in the understanding and treatment of cystic fibrosis. Curr Opin Pulm Med 1998;4(3):130-4.
7. Conrad DJ. The arachidonate 12/15-lipoxygenases: A review of tissue expression and biological function. Clin Rev Allergy Immun 1999;17(1-2):17-89.
8. Huang JT, Welsh JS, Ricote M, Kelly C, Binder C, Willson TM, Witzum JL, Funk C, Conrad DJ, Glass C. Interleukin-4-dependent production of PPAR-g ligands in macrophages by 12/15-lipoxygenase. Nature 1999:400:378-82.
9. Conrad DJ, Lu M. Regulation of human airway 12/15-lipoxygenase by STAT6 dependent transcription. Am J Respir Cell Mol Biol 1999. In press
10. Conrad DJ, Lu M. 3'-Terminal sequences of the 12/15-lipoxygenase gene mediates its regulation by Interferon-g. 1999. In preparation.