Roger G. Spragg, MD

Professor of Medicine Chief, Medicine Service, La Jolla VA Medical Center Vice Chair, Department of Medicine, UC San Diego

CLINICAL INTERESTS:

Acute lung injury

INVESTIGATIVE INTERESTS:

1. Pathology of the surfactant system of the mature lung
2. Mechanisms of acute lung injury

SELECTED PUBLICATIONS:

1. Smith RM, Traber DL, Spragg RG. Pulmonary deposition and clearance of aerosolized alpha-1-proteinase inhibitor administered to dogs and sheep. J Clin Invest 1989;84:1145-54.
2. Gilliard N, Richman PM, Merritt TA, Spragg R.G. Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis 1990;141:743-7.
3. Spragg R.G. DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol 1991;4:4-10.
4. Gilliard N, Pappert D, Merritt TA, Heldt G, Spragg R.G. Radiolabeling of the hydrophobic components of lung surfactant with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazerine. Ann Biochem 1991;193:310-5.
5. Spragg RG, Smith RM. Biology of acute lung injury. In The Lung: Scientific Foundation. Crystal RG, West JB, editors. New York: Raven Press. pp. 2003-17, 1991.
6. Montisano DF, Mann T, Spragg R.G. Exposure of pulmonary artery endothelial cells to H2O2 causes increased expression of platelet derived growth factor mRNA. J Appl Physiol 1992;73:2255-62.
7. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall R, Morris A, Spragg R.G. The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical coordination. Am Rev Respir Dis 1994;149:818-24.
8. Gilliard N, Heldt P, Loredo J, Gasser H, Redl H, Merritt TA, Spragg R.G. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. J Clin Invest 1994;93:2608-15.
9. Gilliard N, Pappert D, Spragg R.G. Factual analysis of surfactant deposition in rabbit lungs. J Appl Physiol 1995;78:862-6.
10. Chao W, Spragg RG, Smith RM. Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils: Attenuation of p47phox and p67phox membrane translocation as the mechanism. J Clin Invest 1995;96:2654-60.
11. Hastings RH, Summers-Torres D, Cheung TC, Ditmer LS, Burton DW, Spragg RG, Li J, Deftos LJ. Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells. Am J Physiol 1996;14:L353-61.
12. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan P, Nielson H, Spragg RG, Watterberg K, Dieter G. Human SP-A Locus: Allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol 1996;15:489-98.
13. Ahuja A, Oh H, Chao W, Spragg RG, Smith RM. Inhibition of the human neutrophil respiratory burst by native and synthetic surfactant. Am J Respir Cell Mol Biol 1996;14:496-503.
14. Gregory TJ, Steinberg KP, Spragg RG, Gadek JE, Hyers TM, Longmore WJ, Moxley MA, Cai GZ, Hite RD, Smith RM, Hudson D, Crim C, Newton P, Mitchell BR, Gold AJ. Bovine surfactant therapy for patients with the acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;155:1309-15.
15. Hopkins SR, Schoene RB, Henderson WR, Spragg RG, Martin TR, West JB. Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. Am J Respir Crit Care Med 1996;155:1090-4.
16. Spragg RG, Smith RM. Pathology of the surfactant system of the mature lung. Am J Respir Crit Care Med 1997;155:756-60.
17. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marin JJ, Matthay MA, Pinsky MR, Spragg RG, Suter PM. The American-European Consensus Conference on ARDS, Part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Am J Respir Crit Care Med 1998;157:1332-47.
18. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg RG, Suter PM. The American-European Consensus Conference on ARDS, Part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Intensive Care Medicine 24:378-398, 1998.
19. Dresselhaus TR, Luck J, Wright BD, Spragg RG, Lee ML, Bozzette SA. Analyzing the Time and Value of Housestaff Inpatient Work. J Gen Intern Med 13:534-540, 1998.
20. Lewis J, McCaig L, Haefner D, Spragg RG, Veldjuizen R, Kerr C. Dosing and Delivery of a Recombinant Surfactant in Lung-Injured Adult Sheep. Am J Respir Crit Care Med, Mar. 159(3):741-747, 1999.
21. Spragg RG, Smith RM, Harris K, Lewis J, Haefner D, Germann P. Effect of Recombinant SP-C Surfactant in a Porcine Lavage Model of Acute Lung Injury. J Appl Physiol 88:674-681, 2000.
22. Spragg RG, Li J. Effect of Phosphocholine Cytidylyltransferase Overexpression on Phosphatidylcholine Synthesis on Alveoar Type II Cells and Related Cell Lines. Am J Respir Cell Mol Biol Vol 22:116-124, 2000.
23. Permpikul C, Wang H-Y, Kriett J, Konopka RG, Moser KM, Spragg R.G. Reperfusion Lung Injury After Unilateral Pulmonary Artery Occlusion. Respirology 5:133-140, 2000.
24. The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. New Engl J Med 342:1301-1308, 2000.
25. Li J, Marsh JJ, Spragg R.G. Effect of CTP:Phosphocholine Cytidylyltransferase Overexpression on the Mouse Lung Surfactant System. Am J Respir Cell Mol Biol 26:1-7, 2002.
26. Spragg RG, Lewis J. Surfactant Therapy in the Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome of the Lung Biology and Health and Disease Series. M. Matthay, ed. Marcel Dekker, Inc, New York, Vol 179:533-562, 2003.
27. Spragg R.G., Lewis, J.F., Wurst, W., Haefner, D., Baughman, R.P., Wewers, M.D., Marsh, J.J. Treatment of the Acute Respiratory Distress Syndrome with rSP-C Surfactant. Am. J. Respir. Crit. Care Med. 167:1562-1566, 2003.
28. Spragg R.G., Ponganis, P.J., Marsh, J.J., Rau,G.A., Bernhard, W. Surfactant From Diving Aquatic Mammals, J. Appl. Physiol. [Epub Dec 19, 2003 ahead of print] in press.