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Publications

Selected Publications

Books

  1. Barrett, K.E., S.M. Barman, H.L. Brooks and J.X.-J. Yuan. Ganong's Review of Medical Physiology (26thEdition). McGraw Hill/Lange, New York, NY, 2019 (742 pages). ISBN: 978-1-260-566666-6; MHID: 1-260-56666-8.
  2. Firth, A. and J.X.-J. Yuan (eds) Lung Stem Cells in the Epithelium and Vasculature. Humana Press/SpringerCham Heidelberg New York Dordrecht London, 2015. ISBN: 978-3-319-16231-7
  3. Yuan, J.X.-J., J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer, and J.B. West (eds) Textbook of PulmonaryVascular Disease. Springer, New York, NY. 2011. ISBN:978-0-387-87428-9
  4. Yuan, J.X.-J. and Jeremy P.T. Ward (eds) Membrane Receptors, Channels, and Transporters in PulmonaryCirculation. Humana Press-Springer, New York, NY, 2010. ISBN:978-1-60761-499-9
  5. Yuan, J.X.-J. (ed) Ion Channels in the Pulmonary Vasculature. Taylor & Francis Group, Boca Raton, FL, 2005. ISBN-13:978-0-8247-5968-1
  6. Yuan, J.X.-J. (ed) Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. KluwerAcademic Publishers, Boston, MA, 2004. ISBN: 978-1-4020-7857-6
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Original Research Articles

  1. Jain, P.R., T. Zhao, M. Xiong, S. Song, N. Lai, J. Chen, S.G. Carr, A. Babicheva, M. Rodriguez, S. Rahimi, F. Balistrieri, S. Rahimi, T. Simonson, D. Valdez-Jasso, P.A. Thistlethwaite, J.Y.-J. Shyy, J. Wang, A. Makino, and J.X.-J. Yuan. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br. J. Pharmacol. In press (Mar 10. doi: 10.1111/bph.15442. Online ahead of print), 2021. PMID: 33694155.
  2. Romanoski, C.E., X. Qi, S. Sangam, R.R. Vanderpool, R.S. Spearman, A. Conklin, M. Gonzalez-Garay, F. Rischard, R.J. Ayon, J. Wang, T. Simonson, A. Babicheva, Y. Shi, H. Tang, A. Makino, Y. Kanthi, M.W. Geraci, J.G.N. Garcia, J.X.-J. Yuan, and A.A. Desai. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm. Circ. 10: 2045894020968531, 2020. PMID: 33343881.
  3. Shen, H., J. Zhang, C. Wang, P.P. Jain, M. Xiong, X. Shi, Y. Lei, S. Chen, Q. Yin, P.A. Thistlethwaite, J. Wang, K. Gong, Z.-Y. Yuan, J.X.-J. Yuan, and J.Y.-J. Shyy. MDM2-mediated ubiquitination of ACE2 contributes to the development of pulmonary arterial hypertension. Circulation. 142:1190-1204, 2020. PMID: 32755395
  4. Song, S., A. Babicheva, T. Zhao, R.J. Ayon, M. Rodriguez, S. Rahimi, F. Balistrieri, A. Harrington, J.Y. Shyy, P.A. Thistlethwaite, A. Makino and J.X.-J. Yuan. Notch enhances Ca2+ entry by activating calcium-sensing receptor and inhibiting voltage-gated K+ channels. Am. J. Physiol. Cell Physiol. 318: C954-C968, 2020. PMID: 32186932.
  5. Sun, X., B.L. Sun, A. Babicheva, R. Vanderpool, R.C. Oita, N. Casanova, H. Tang, A. Gupta, H. Lynn, G. Gupta, F. Rischard, S. Sammani, C.L. Kempf, L. Moreno-Vinasco, M. Ahmed, S.M. Camp, J. Wang, A.A. Desai, J.X.-J. Yuan, and J.G.N. Garcia. Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling: Transcriptional regulation by SOX and HIF-2α. Am. J. Respir. Cell Mol. Biol. 63: 92- 103, 2020. PMID: 32146329.
  6. Karnes, J.H., H.W. Wiener, T.H. Schwantes-An, B. Natarajan, A.J. Sweatt, A. Chaturvedi, A. Arora, K. Batai, V. Nair, H.E. Steiner, J.B. Giles, J. Yu, M. Hosseini, M.W. Pauciulo, K.A. Luts, A.W. Coleman, J. Feldman, R. Vanderpool, H. Tang, J.G.N. Garcia, J.X-J. Yuan, R. Kittles, V.D. Perez, R.T. Zamanian, F. Rischard, H.K. Tiwari, W.C. Nichols, R.L. Benza, and A.A. Desai. Genetic admixture and survival in diverse populations with pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 201: 1407-1415, 2020. PMID:31916850.
  7. Babicheva, A., R.J. Ayon, T. Zhao, J.F. Ek Vitorin, N.M. Pohl, A. Yamamura, H. Yamamura, B.A. Quinton, M. Ba, L. Wu, K.S. Ravellette, S. Rahim, F. Balistrieri, A. Harington, R.R. Vanderpool, P.A. Thistlethwaite, A. Makino and J.X.-J. Yuan. MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 318: L10-L26, 2020. PMID: 31553627.
  8. Vanderpool, R.R., R. Puri, A. Osorio, K. Wickstrom, A.A. Desai, S.M. Black, J.G.N. Garcia, J.X.-J. Yuan and F.P. Rischard. Surfing the right ventricular pressure waveform: Methods to assess global, systolic and diastolic RV function from a clinical right heart catheterization. Pulm. Circ. 10: 1-11, 2020. PMID: 31032737.
  9. Tang, H., K. Wu, J. Wang, S. Vinjamuri, Y. Gu, S. Song, Z. Wang, Q. Zhang, A. Balistrieri, R.J. Ayon, F. Rischard, R. Vanderpool, J. Chen, G. Zhou, A.A. Desai, S.M. Black, J.G.N. Garcia, J.X.-J. Yuan, and A. Makino. Pathogenic role of mTORC1 and mTORC2 in pulmonary hypertension. JACC. Basic Trans. Sci. 3: 744-762, 2018. PMID: 30623134
  10. Song, S., S.G. Carr, K.M. McDermott, M. Rodriguez, A. Babicheva, A. Balistrieri, R.J. Ayon, J. Wang, A. Makino, and J.X.-J. Yuan. STIM2-mediated increase in resting [Ca2+]cyt stimulates PASMC proliferation in pulmonary arterial hypertension. Hypertension. 71: 518-529, 2018. PMID: 29358461.
  11. Tang, H., A. Babicheva, K.M. McDermott, Y. Gu, R.J. Ayon, S. Song, Z. Wang, A. Gupta, T. Zhou, X. Sun, S. Dash, Z. Wang, A. Balistrieri, Q. Zheng, A.G. Cordery, A.A. Desai, F. Rischard, Z. Khalpey, J. Wang, S.M. Black, J.G.N. Garcia, A. Makino, and J.X.-J. Yuan. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am. J. Physiol. Lung Cell. Mol. Physiol. 314: L256- L275, 2018. PMID: 29074488.
  12. Song, S., A. Yamamura, H. Yamamura, A. Babicheva, R.J. Ayon, S. Dash, X. Sun, H. Tang, S.M. Black, A. Desai, F. Rischard, K. M. McDermott, A. Makino, and J.X.-J. Yuan. Capsaicin-induced Ca2+ signaling is enhanced via overexpressed TRPV1 channels in pulmonary arterial smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 312: L309-L325, 2017. PMID: 27979859.
  13. Chen, J., J.R. Sysol, S. Singla, S. Zhao, A. Yamamura, D. Valdez-Jasso, T. Abbasi, K.M. Shioura, S. Sahni, V. Reddy, A. Sridhar, H. Gao, J. Torres, S.M. Camp, H. Tang, S.Q. Ye, S. Comhair, R. Dweik, P. Hassoun, J.X.-J. Yuan, J.G.N. Garcia, R.F. Machado. 135: 1532-1546, 2017. PMID: 28202489
  14. Hemnes, A.R., G.J. Beck, J.H. Newman, A. Abidov, M.A. Aldred, J. Barnard, E.B. Rosenzweig, B.A. Borlaug,W.K. Chung, S.A.A. Comhair, S.C. Erzurum, R.P. Frantz, M.P. Gray, G. Grunig, P.M. Hassoun, N.S. Hill, E.M. Horn, B. Hu, J.K. Lempel, B.A. Maron, S.C. Mathai, M.A. Olman, F.P. Rischard, D.M. Systrom, W.H.W. Tang, A.B. Waxman, L. Xiao, J.X.-J. Yuan, J.A. Leopold, and the PVDOMICS Study Group. PVDOMICS: A multi- center study to improve understanding of pulmonary vascular disease through phenomics. Circ. Res. 121: 1136-1139, 2017. PMID: 29074534.
  15. Burg, E.D., O. Platoshyn, I.F. Tsigelny, B. Lozano-Ruiz, B.K. Rana and J.X.-J. Yuan. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am. J. Physiol. Cell Physiol. 298: C496-C509, 2010. PMID: 20018952.
  16. Firth, A.L., W. Yao, C.V. Remillard, A. Ogawa, and J.X.-J. Yuan. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 298: L548-L557, 2010. PMID: 20139178.
  17. Firth, A.L., W. Yao, A. Ogawa, M.M. Madani, G.L. Lin, and J.X.-J. Yuan. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Cell Physiol. 298: C1217-C1225, 2010. PMID: 20181931.
  18. Tang, H., A. Yamamura, H. Yamamura, S. Song, D.R. Fraidenburg, J. Chen, Y. Gu, T. Zhou, L. Jiménez- Peréz, R.J. Ayon, A. Desai, D. Goltzman, F. Rischard, Z. Khalpey, S. M. Black, J.G.N. Garcia, A. Makino, and J.X.-J. Yuan. Pathogenic Role of calcium-sensing receptors (CaSR) in the development and progression of pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 310: L846-L859, 2016. PMID: 26968768.
  19. Tang, H., J. Chen, D.R. Fraidenburg, S. Song, K.A. Smith, A.R. Drennan, S. Offermanns, R.D. Ye, M.G. Bonini, R.D. Minshall, J.G.N. Garcia, R.F. Machado, A. Makino, and J.X.-J. Yuan. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 308: L208- L220, 2015. PMID: 25416348.
  20. Fernandez, R.A., J. Wan, S. Song, K.A. Smith, Y. Gu, M. Tauseef, H. Tang, A. Makino, D. Mehta, and J.X.-J. Yuan. Upregulated expression of STIM2, TRPC6 and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am. J. Physiol. Cell Physiol. 308: C581- C593, 2015. PMID: 25673771.
  21. Smith, K.A., G. Voiriot, H. Tang, D.R. Fraidenburg, S. Song, H. Yamamura, Y. Yamamura, Q. Guo, N.M. Pohl, M. Tauseef, R. Bodmer, K. Ocorr, P.A. Thistlethwaite, G.G. Haddad, F.L. Powell, A. Makino, D. Mehta, and J.X.-J. Yuan. Notch activation of Ca2+ signaling in the development of hypoxic pulmonary vasoconstriction and pulmonary hypertension. Am. J. Respir. Cell. Mol. Biol. 53: 355-367, 2015. PMID: 25569851.
  22. Yamamura, H., A. Yamamura, E.A. Ko, N.M. Pohl, K.A. Smith, F.L. Powell, P.A. Thistlethwaite, and J.X.-J. Yuan. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 306: C871-878, 2014. PMID: 24573085.
  23. Song, S, A. Yamamura, H. Yamamura, R.J. Ayon, K.A. Smith, H. Tang, A. Makino, and J.X.-J. Yuan. Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Cell Physiol. 307: C373-C383, 2014. PMID: 24920677.
  24. Lanthan, C., Y. Zhang, J. Chow, M. Singh, G. Lin, V. Nigam, Y.A. Ashraf, J.X.-J. Yuan, I. Robbins, and P.A. Thistlethwaite. ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno- occlusive disease. Circulation. 130: 1179-1191, 2014. PMID: 25062690.
  25. Yoo, H.Y., A. Zeifman, E.A. Ko, K.A. Smith, J. Chen, R.F. Machado, Y.-Y. Zhao, R.D. Minshall, and J.X.-J. Yuan. Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction. Pulm. Circ. 3: 396-405, 2013. PMID: 24015341.
  26. Yamamura, A., H. Yamamura, Q. Guo, A.M. Zimnicka, J. Wan, E.A. Ko, K.A. Smith, N.M. Pohl, S. Song, A. Zeifman, A. Makino, and J.X.-J. Yuan. Dihydropyridine Ca2+ channel blockers increase cytosolic [Ca2+] by activating Ca2+-sensing receptors in pulmonary arterial smooth muscle cells. Circ. Res. 112: 640-650, 2013. PMID: 23300272.
  27. Ko, E.A., J. Wan, A. Yamamura, A.M. Zimnicka, H. Yamamura, H.Y. Yoo, H. Tang, K.A. Smith, P.C. Sundivakkam, A. Zeifman, R.J. Ayon, A. Makino, and J.X.-J. Yuan. Functional characterization of voltage- dependent Ca2+ channels in mouse pulmonary artery smooth muscle cells: Divergent effect of ROS. Am. J. Physiol. Cell Physiol. 304: 1042-1052, 2013. PMID: 23426966.
  28. Ogawa, A., A.L. Firth, K.A. Smith, M.V. Maliakal, and J.X.-J. Yuan. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am. J. Physiol. Cell Physiol. 302: C405-C411, 2012. PMID: 22031597.
  29. Yamamura, A., Q. Guo, H. Yamamura, A.M. Zimnicka, N.M. Pohl, K.A. Smith, R.A. Fernandez, A. Zeifman, A. Makino, H. Dong, and J.X.-J. Yuan. Enhanced Ca2+-sensing receptor function in pulmonary arterial hypertension. Circ. Res. 111: 469-481, 2012. PMID: 22730443.
  30. Yu, Y., S.H. Keller, C.V. Remillard, O. Safrina, A. Nicholson, S.L. Zhang, W. Jiang, N. Vangala, J.W. Landsberg, J.-Y. Wang, P.A. Thistlethwaite, R.N. Channick, I.M. Robbins, J.E. Loyd, H.A. Ghofrani, F. Grimminger, R.T. Schermuly, M.D. Cahalan, L.J. Rubin, and J.X.-J. Yuan. A functional single nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 119:2313-2322, 2009. PMID: 19380626.
  31. Yao, W., A.L. Firth, R.S. Sacks, A. Ogawa, W.R. Auger, P.F. Fedullo, M.M. Madani, N. Sakakibara, G.Y. Lin, P.A. Thistlethwaite, S.W. Jamieson, L.J. Rubin and J.X.-J. Yuan. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L870-L878, 2009. PMID: 19286928.
  32. Li, X., X. Zhang, R. Leathers, A. Makino, C. Huang, P. Parsa, J. Macias, J.X.-J. Yuan, S.W. Jamieson, and P.A. Thistlethwaite. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15: 1289-1297, 2009. PMID: 19855400.
  33. Zhang, S., H. Dong, L.J. Rubin, and J.X.-J. Yuan. Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am. J. Physiol. Cell Physiol. 292: C2297-C2305, 2007. PMID: 17192285.
  34. Platoshyn, O., Y. Yu, C.V. Remillard, and J.X.-J. Yuan. Heterogeneity of acute hypoxia-induced decrease in I< class="s4" style="font-stretch: normal; font-size: 8px; line-height: normal;">K(V) and increase in [Ca2+]cyt in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L402-L416, 2007. PMID: 17526598.
  35. Ko, E.A., E.D. Burg, O. Platoshyn, J. Msefya, A.L. Firth, and J.X.-J. Yuan. Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 293: C928-C937, 2007. PMID: 17581857.
  36. Platoshyn, O., E.E. Brevnova, E.D. Burg, Y. Yu, C.V. Remillard, and J.X.-J. Yuan. Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 290: C907- C916, 2006. PMID: 16236819.
  37. Laugwitz, K.-L., A. Moretti, J. Lam, P. Gruber, Y. Chen, S. Woodard, L.-Z. Lin, C.-L. Cai, M.M. Lu, M. Reth, O. Platoshyn, J.X.-J. Yuan, S. Evans, and K.R. Chien. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 433: 647-653, 2005. PMID: 15703750.
  38. Platoshyn, O., I. Fantozzi, C.V. Remillard, T.T. Sison, and J.X.-J. Yuan. Identification of functional voltage- gated Na+ channels in human pulmonary artery smooth muscle cells. Pflügers Arch. - Eur. J. Physiol. 451: 380-387, 2005. PMID: 16052353.
  39. Brevnova, E.E., O. Platoshyn, S. Zhang, and J.X.-J. Yuan. Overexpression of human KCNA5 increases IK(V) and enhances apoptosis. Am. J. Physiol. Cell Physiol. 287: C715-C722, 2004. PMID: 15140747.
  40. Yu, Y., I. Fantozzi, C.V. Remillard, J.W. Landsberg, N. Kunichika, O. Platoshyn, D.D. Tigno, P.A. Thistlethwaite, L.J. Rubin, and J.X.-J. Yuan. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc. Natl. Acad. Sci. USA. 101: 13861-13866, 2004. PMID: 15358862.
  41. Kunichika, N, J.W. Landsberg, Y. Yu, H. Kunichika, P.A. Thistlethwaite, L.J. Rubin, and J.X.-J. Yuan. Bosentan inhibits transient receptor potential channels in human pulmonary vascular myocytes. Am. J. Respir. Crit. Care Med. 170: 1101-1107, 2004. PMID: 15317671.< class="Apple-converted-space">
  42. Yu, Y., M. Sweeney, S. Zhang, O. Platoshyn, J. Landsberg, A. Rothman, and J.X.-J. Yuan. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am. J. Physiol. Cell Physiol. 284: C316-C330, 2003. PMID: 12529250.
  43. Ekhterae, D., O. Platoshyn, S. Zhang, C.V. Remillard, and J.X.-J. Yuan. Apoptosis repressor with caspase domain inhibits cardiomycyte apoptosis by reducing K+ currents. Am. J. Physiol. Cell Physiol. 284: C1405- C1515, 2003. PMID: 11401838.
  44. Du, L., C.C. Sullivan, D. Chu, A.J. Cho, M. Kido, P.L. Wolf, J.X.-J. Yuan, R. Deutsch, S.W. Jamieson, and P.A. Thistlethwaite. Signaling molecules in nonfamilial pulmonary hypertension. N. Engl. J. Med. 348: 500- 509, 2003. PMID: 12571257.
  45. Krick, S., O. Platoshyn, M. Sweeney, S.S. McDaniel, S. Zhang, L.J. Rubin, and J.X.-J. Yuan. Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cell. Am. J. Physiol. Heart Circ. Physiol. 282: H184-H193, 2002. PMID: 11748062.
  46. Sweeney, M., S.S. McDaniel, O. Platoshyn, S. Zhang, Y. Yu, B.R. Lapp, Y. Zhao, P.A. Thistlethwaite, and J.X.-J. Yuan. Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J. Appl. Physiol. 92: 1594-1602, 2002. PMID: 11896026.
  47. Sweeney, M., Y. Yu, O. Platoshyn, S. Zhang, S.S. McDaniel, and J.X.-J. Yuan. Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell growth. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L144-L155, 2002. PMID: 12060571.
  48. Platoshyn, O., S. Zhang, S.S. McDaniel, and J.X.-J. Yuan. Cytochrome c activates K+ channels prior to inducing apoptosis. Am. J. Physiol. Cell Physiol. 283: C1298-C1305, 2002. PMID: 12225922.
  49. Golovina, V.A., O. Platoshyn, C.L. Bailey, J. Wang, A. Limsuwan, M. Sweeney, L.J. Rubin, and J.X.-J. Yuan. Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation. Am. J. Physiol. Heart Circ. Physiol. 280: H746-H755, 2001. PMID: 11158974.
  50. McDaniel, S.S., O. Platoshyn, J. Wang, Y. Yu, M. Sweeney, S. Krick, L.J. Rubin, and J.X.-J. Yuan. Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction. Am.J. Physiol. Lung Cell. Mol. Physiol. 280: L870-L880, 2001. PMID: 11290510.
  51. Krick, S., O. Platoshyn, M. Sweeney, H. Kim, and J.X.-J. Yuan. Activation of K+ channels induces apoptosis in vascular smooth muscle cells. Am.J. Physiol. Cell Physiol. 280: C970-C979, 2001. PMID: 11245614.
  52. McDaniel, S.S., O. Platoshyn, Y. Yu, M. Sweeney, V.A. Miriel, V.A. Golovina, S. Krick, Lapp BR, J.-Y. Wang, and J.X.-J. Yuan. Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells. J. Appl. Physiol. 91: 2322-2333, 2001. PMID: 11641377.
  53. Yu, Y., O. Platoshyn, J. Zhang, S. Krick, Y. Zhao, L. J. Rubin, A. Rothman, and J.X.-J. Yuan. c-Jun decreases voltage-gated K+ channel activity in pulmonary artery smooth muscle cells. Circulation 104:1557-1563, 2001. PMID: 11571252.
  54. Yuan, X.-J., J. Wang, M. Juhaszova, S.P. Gaine, and L.J. Rubin. Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet. 351(9104): 726-727, 1998. PMID: 9504523.
  55. Yuan, J.X.-J., A.M. Aldinger, M. Juhaszova, J. Wang, J.V. Conte, S.P. Gaine, J.B. Orens, and L.J. Rubin. Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation. 98: 1400-1406, 1998. PMID: 9760294.
  56. Wang, J., M. Juhaszova, J.V. Conte, Jr., S.P. Gaine, L.J. Rubin, and J.X.-J. Yuan. Action of fenfluramine on voltage-gated K+ channels in human pulmonary-artery smooth-muscle cells. Lancet. 352(9124): 290, 1998. PMID: 9690417.
  57. Yuan, X.-J. Role of calcium-activated chloride current in regulating pulmonary vasomotor tone. Am. J. Physiol. 272: L959-L968, 1997. PMID: 9176262.
  58. Wang, J., M. Juhaszova, L.J. Rubin, and X.-J. Yuan. Hypoxia inhibits gene expression of voltage-gated K+ channel α-subunits in pulmonary artery smooth muscle cells. J. Clin. Invest. 100: 2347-2353, 1997. PMID: 9410914.
  59. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. Proc. Natl. Acad. Sci. USA 93: 10489-10494, 1996. PMID: 8816828.
  60. Yuan, X.-J. Voltage-gated K+ Currents regulate resting membrane potential and [Ca2+]i in pulmonary artery myocytes. Circ. Res. 77: 370-378, 1995. PMID: 7542182.
  61. Yuan, X.-J., W.F. Goldman, M.L. Tod, L.J. Rubin and M.P. Blaustein. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264: L116-L123, 1993. PMID: 8447425.

Review Articles

  1. Babicheva, A., A. Makino and J.X.-J. Yuan. mTOR signaling in pulmonary vascular disease: Pathogenic role and therapeutic target. Int. J. Mol. Sci. 22: 2144, 2021. PMID: 33670032
  2. Gassmann, M., A. Cowburn, H. Gu, J. Li, M. Rodriguez, A. Babicheva, P.P. Jain, M. Xiong, N.N. Gassmann, J.X.-J. Yuan, M.R. Wilkins, and L. Zhao. Hypoxia-induced pulmonary hypertension- Utilising experiments of nature. Br. J. Pharmacol. 178: 121-131, 2020.
  3. Smith, K.A., R.J. Ayon, H. Tang, A. Makino, J.X.-J. Yuan. Front Physiol. 7:517, 2016. PMID: 27867361.
  4. Lang, I.M., R. Pesavento, D. Bonderman, and J.X.-J. Yuan. Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur. Respir. J. 41: 462-468, 2013. PMID: 22700839.
  5. Kuhr, F.K., K.A. Smith, M.Y. Song, Levitan I and J.X.-J. Yuan. New mechanisms of pulmonary hypertension: Role of Ca2+ signaling. Am. J. Physiol. Heart Circ. Physiol. 302: H1546-H1562, 2012. PMID: 22245772.
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