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Division of Pulmonary, Critical Care, Sleep Medicine & Physiology Division of Pulmonary, Critical Care, Sleep Medicine & Physiology
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Publications

Heinrich EC, Wu L, Lawrence ES, Cole AM, Ramirez CA, Villafuete FC, Simonson TS. Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans. Annals of Human Genetics 2019 83:171-176. doi: 10.1111/ahg.12299.

Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Bosompra, Wu L, Ramirez CA, Orr JE, Powell FL, Malhotra A, Simonson TS. Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. PLoS One. 2019 Jun 12;14(6):e0217089. doi: 10.1371/journal.pone.0217089.

Orr JE, Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Anza-Ramirez C, Villafuerte FC, Powell FL, Malhotra A, and Simonson TS. Adaptive servoventilation as treatment for central sleep apnea due to high-altitude periodic breathing in non-acclimatized healthy individuals. High Altitude Medicine and Biology. 2018 doi: 10.1089/ham.2017.0147.

Sá, RC, Cortney Henderson A, Simonson TS, Arai TJ, Wagner H, Theilmann RJ, Wagner PD, Prisk GK and Hopkins SR. Measurement of the distribution of ventilation-perfusion ratios in the human lung with proton MRI: comparison with the multiple inert gas elimination technique. J. Appl. Physiol. 2017 123(1): 136-146.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB*, Robbins PA*, Simonson TS*, Huff CD*. Evolutionary history of Tibetans inferred from whole-genome sequencing. PLOS Genetics 2017 13(4): e1006675.

Simonson TS, Wagner PD. Oxygen transport adaptations to exercise in native highland populations. Exp Physiol. 2015 Nov 1;100(11):1231-2. PubMed PMID: 26575339.

Elliott BT, Simonson TS, Getting SJ, Renshaw D, Wagner PD, Mackenzie RWA. Acute hypoxia reduces plasma myostatin independent of hypoxic dose J. Cachexia Sarcopenia Muscle 2015. 6(4): 435.

Wagner PD, Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Ge RL. Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m. Exp Physiol. 2015 Nov 1;100(11):1256-62. PubMed PMID: 26454003.

Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB. Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Exp Physiol. 2015 Nov 1;100(11):1263-8. PubMed PMID: 26454145.

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA. Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov 1;100(11):1247-55. PubMed PMID: 26053282.

Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Wagner PD, Ge RL. Low hemoglobin concentration in Tibetan males is associated with greater exercise capacity. J Physiol. 2015 July 15;593(14):3207-18. Doi:10.1113/JP270518. Epub Jun 25; PMID: 25988759.

Simonson TS. Altitude adaptation: A glimpse through various lenses. High Altitude Medicine and Biology. 2015 Jun; 16(2):125-37. doi: 10.1089/ham.2015.0033. PMID: 26070057. [Invited Review]

Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL. Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. Exp Physiol. 2014 Aug 28; PMID: 25172885. [Reply: doi: 10.1113/EP085032. PMID: 25720665]

Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep;46(9):951-6. PMID: 25129147.

Simonson TS and Powell FL. Less is more: blunted responses to hypoxia revealed in Tibetan residents at sea level. J Appl Physiol (1985). 2013 Oct 10. [Epub ahead of print] PMID: 24114703.

Xing J, Wuren T, and Simonson TS, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL. Genomic analysis of natural selection and phenotypic variation in high-altitude Mongolians. PLoS Genet. 2013 July 18. 9(7): e1003634. doi:10.1371/journal.pgen.1003634. PMID: 23874230.

Simonson TS and Ge RL, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Mar 17. [Epub ahead of print] PubMed PMID: 22503288.

Simonson TS, McClain DA, Jorde LB, Prchal JT. Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr;131(4):527-33. doi: 10.1007/s00439-011-1109-3. Epub 2011 Nov 9. PubMed PMID: 22068265.

Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL. Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol. 2012 Jan;29(1):101-11. Epub 2011 Aug 4. PubMed PMID: 21816865; PubMed Central PMCID: PMC3245542.

Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB. Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. 2011 May;21(5):768-74. Epub 2011 Feb 8. PubMed PMID: 21324875; PubMed Central PMCID: PMC3083094.

Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB. Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes. PLoS One. 2011 Jan 31;6(1):e16338. PubMed PMID: 21305013; PubMed Central PMCID: PMC3031551.

Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB. Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping. Genomics. 2010 Oct;96(4):199-210. Epub 2010 Jul 16. PubMed PMID: 20643205; PubMed Central PMCID: PMC2945611.

Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. Genetic evidence for high-altitude adaptation in Tibet. Science. 2010 Jul 2;329(5987):72-5. Epub 2010 May 13. PubMed PMID: 20466884.

Simonson TS, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB. Limited distribution of a cardiomyopathy-associated variant in India. Ann Hum Genet. 2010 Mar;74(2):184-8. Epub 2010 Feb 18. PubMed PMID:20201939; PubMed Central PMCID: PMC2901538.

Lorenzo VF, Yang Y, Simonson TS, Nussenzveig R, Jorde LB, Prchal JT, Ge RL. Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis. 2009 Nov-Dec;43(3):221-5. Epub 2009 May 29. Partial retraction in: Blood Cells Mol Dis. 2010 Mar 15;44(3):198. PubMed PMID: 19481479.

Simonson TS, Okinaka RT, Wang B, Easterday WR, Huynh L, U'Ren JM, Dukerich M, Zanecki SR, Kenefic LJ, Beaudry J, Schupp JM, Pearson T, Wagner DM, Hoffmaster A, Ravel J, Keim P. Bacillus anthracis in China and its relationship to worldwide lineages. BMC Microbiol. 2009 Apr 15;9:71. PubMed PMID: 19368722; PubMed Central PMCID: PMC2674057.

Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, Zanecki SR, Pearson T, Simonson TS, U'Ren JM, Kachur SM, Leadem-Dougherty RR, Rhoton SD, Zinser G, Farlow J, Coker PR, Smith KL, Wang B, Kenefic LJ, Fraser-Liggett CM, Wagner DM, Keim P. Global genetic population structure of Bacillus anthracis. PLoS One. 2007 May 23;2(5):e461. PubMed PMID: 17520020; PubMed Central PMCID: PMC1866244.

Van Ert MN, Easterday WR, Simonson TS, U'Ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P. Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain. J Clin Microbiol. 2007 Jan;45(1):47-53. Epub 2006 Nov 8. PubMed PMID: 17093023; PubMed Central PMCID: PMC1828967.

U'Ren JM, Van Ert MN, Schupp JM, Easterday WR, Simonson TS, Okinaka RT, Pearson T, Keim P. Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol. 2005 Nov;43(11):5771-4. PubMed PMID: 16272516; PubMed Central PMCID: PMC1287822.

Easterday WR, Van Ert MN, Simonson TS, Wagner DM, Kenefic LJ, Allender CJ, Keim P. Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis. J Clin Microbiol. 2005 Apr;43(4):1995-7. PubMed PMID: 15815042; PubMed Central PMCID: PMC1081367.

Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson TS, Keim P. Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis. Biotechniques. 2004 Oct;37(4):642-4, 646, 648 passim. PubMed PMID: 15517976.

Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson TS, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13536-41. Epub 2004 Sep 3. PubMed PMID: 15347815; PubMed Central PMCID: PMC518758.