Resources

Centers at UC San Diego

Center for Physiological Genomics of Low Oxygen (CPGLO)
Center for Computational Biology & Bioinformatics

In the News

Science Magazine "Two mountaineers are trying to recreate NASA's twin study-on Mount Everest"
The Scientist "Free Divers from Southeast Asia Evolved Bigger Spleens"
The Scientist "The Genetic Strategies of Dealing with High Altitude"
Seeker "Sherpa Resiliency at High Altitudes Begins on the Molecular Level"
National Public Radio "The Science Behind the Super Abilities of Sherpas"
British Broadcasting Company (BBC) "How Tibetans Survive Life on the Roof of the World"

Simonson Lab Poster Presentations, 2018

Experimental Biology Meeting, American Physiological Society; San Diego, California

• E.C. Heinrich, C. Anza-Ramirez, M. Tift, J.L. Macarlupu, H.E. Wagner, R. Figueroa-Mujica, G.Vizcardo-Galindo, W. Gu, P.D. Wagner, F.C. Villafuerte, T.S. Simonson (2018) Differences in peak VO2 among healthy Andean highlanders and males with Chronic Mountain Sickness before and after isovolemic hemodilution at 4350m.
• E.C. Heinrich, C. Anza-Ramirez, J.L. Macarlupu, Noemi Corante, G. Vizcardo-Galindo, M. Djokic, F.C. Villafuerte, F.L. Powell, T.S. Simonson (2018) Increased levels of interleukin-6 (IL-6) in Andean males with Chronic Mountain Sickness and sea-level participants after one day at altitude may reflect differences inIL-6 regulation.
• E.S. Lawrence, E.C. Heinrich, L. Wu, F.C. Villafuerte, T.S. Simonson (2018) Genetic missense variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are rare in Andeans.
• G. Yip, E.C. Heinrich, F.C. Villafuerte, T.S. Simonson (2018) Heme-oxygenase 2 (HMOX2) variants associated with evolutionary adaptation and hemoglobin concentration in Tibetans are common in Andean highlanders.

American Thoracic Society Meeting; San Diego, California

• E.C. Heinrich, C. Anza-Ramirez, J.L. Macarlupu, N. Corente, G.Vizcardo-Galindo, M.A. Djokic, F.C. Villafuerte, F.L. Powell, T.S. Simonson (2018) Interleukin 6 is elevated in Andean highlanders with Chronic Mountain Sickness.

• J.E. Orr, E.C. Heinrich, D. Gilbertson, C. Anza-Ramirez, P. Deyoung, M.A. Djokic, G. Vizcardo-Galindo, R. Figueroa-Mujica, A. Mercado, E. Gaio, F.L. Powell, F.C. Villafuerte, A. Malhotra, T.S. Simonson (2018) Association between sleep disordered breathing and erythrocytosis amongst Andean highlanders: the effect of adaptation to altitude

American Society of Human Genetics Meeting; San Diego, California

• E.S. Lawrence, E.C. Heinrich, L. Wu, F.C. Villafuerte, T.S. Simonson (2018) Genetic missense variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are rare in Andeans.

Simonson Lab Invited Presentations, 2018

Department of Integrative Biology Seminar, University of California, Berkeley; Berkeley, California. Physiological and genomic insights into adaptations and mal-adaptations in high-altitude populations

Experimental Biology Meeting, Physiological Genomics Symposium Organizer; San Diego, California. -Omics insights into hypoxic responses and outcomes: From comparative biology to the clinic

Center for Perinatal Biology, Loma Linda University School of Medicine; Loma Linda, California. Cross-population physiological genomic insights into hypoxia adaptation and maladaptation

Center for Better Beginnings Epi & Stats Seminar, University of California, San Diego; San Diego, California. Integrating time scales of adaptation to hypoxia in native highland populations

Department of Human Genetics Seminar, University of Utah; Salt Lake City, Utah. Unraveling adaptive and maladaptive outcomes at altitude: Insights from Mount Everest to Machu Picchu

American Physiological Society Speaker, National Association of Biology Teachers (NABT) Professional Development Conference; San Diego, California. Cross-population insights into hypoxia adaptation and maladaptation